| Their urinary urate concentrations rose after they ate cherries, with peak excretion taking place three hours later. |
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| Diagnosis is by removing fluid from an affected joint or tophus and identifying urate crystals under a polarized-light microscope. |
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| This may be due to genetic factors, but usually drugs including alcohol result in the low urate renal clearance. |
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| Stones can be composed of calcium, oxalate, urate, cystine, xanthine, phosphate, or all of these. |
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| These urate results strongly suggest that cherries can play an important role in fighting gout. |
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| In most cases of gout decreased urinary excretion of urate is the most common metabolic abnormality. |
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| Additional rapid destruction of granulocytes may accompany the initiation of chemotherapy and increase the urate pool. |
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| Gout is known to be caused by the interaction of urate microcrystals with neutrophils. |
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| We have furthermore determined that urate microcrystals altered the phenotype of human neutrophils into a highly pro-inflammatory program. |
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| The slides stained with HE and our method were examined with a light microscope for the presence of urate crystals and diagnostic histologic features of gouty tophus. |
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| This is due in part to the lack of animal models in which the way the kidneys handle monosodium urate is identical to that in man. |
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| Discovered by Sanofi-Synthélabo, rasburicase is an enzyme, urate oxidase, obtained by genetic engineering. |
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| If gout is untreated and the disease becomes advanced, deposits of urate crystals may form into nodules called tophi beneath the skin. |
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| The use of specific antibodies against cell adhesion on bone forming cells activated by urate crystals will be strongly innovative. |
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| Its 80 mg and 120 mg tablets are indicated for the treatment of chronic hyperuricemia in conditions where urate deposition has already occurred. |
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| Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. |
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| Monosodium urate crystals were detected in synovial fluid aspiration, and the patient was diagnosed with gout. |
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| Since 1975, a nonrecombinant form of urate oxidase has been available in Europe and found to be effective in reducing uric acid levels. |
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| Definition: Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi. |
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| Our results show that the most electronegative area of the urate molecule is the N3 site which has the strongest affinity for metal cations. |
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| The Swedish base their reasons for washing table eggs on the possible risks of presence on the shell of parasites, bacteria, viruses, fungus, dust, urate. |
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| Rasburicase, urate oxidase derived from genetic engineering, converts this uric acid into allantoin, a highly soluble compound readily excreted by the kidneys. |
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| The particular nutritional purposes such as 'support of liver function in the case of chronic liver insufficiency', 'reduction of urate stones formation' or 'reduction of the risk of milk fever' can be achieved by feed. |
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| A high level of uric acid can lead to the formation of urate crystals, which settle in joint tissues and ultimately lead to the agonizing symptoms of gouty arthritis. |
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| The times of the fact urate ion typewriter are past. |
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| Regular newsletters and better use o f our csg roup web site is esse ntial to pro viding o ur m em bers hip with up to date acc urate inform ation o n issues of co nce rn an d intere st. |
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| Arthritis was experimentally induced via intra-articular injection of microcrystalline sodium urate suspension into 1 intertarsal joint. |
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| About half of cases involve the big toe, but it can present as gouty tophi, kidney stones, or urate nephropathy. |
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| The kidneys also had focal luminal collecting duct microliths and urate deposition. |
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| The murexide test differentiates urate deposits and calcium deposits. |
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| The deposition of urate crystals in the joints leads to gout. |
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| Urate in blood plasma is a precursor of these uric acid crystals. |
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