| For these reasons, a direct tumorigenic effect that transforms infected hepatocytes into malignant cells is probably unlikely. |
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| This signifies that multiple somatic genetic events are essential for tumorigenic conversion of mesothelial cells. |
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| This process is thought to stimulate tumorigenic growth and to allow the intraductal proliferations to progress to carcinoma. |
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| A tumorigenic ovarian cancer cell line failed to form tumours in athymic mice. |
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| In the rat study,57 antimony was not tumorigenic, as evidenced by a comparison of visible tumours in controls and treated animals at necropsy. |
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| The intent of chronic toxicity testing in animals is to check the possible tumorigenic potential of a chemical. |
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| Carbofuran was not carcinogenic or tumorigenic in the two-year studies in rats and mice, based on both gross and microscopic examinations. |
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| If such a medicinal product is intended to be administered chronically to humans a chronic study may be necessary to detect early tumorigenic effects. |
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| Thus, different oncogenic mutations may give rise to cancers with different tumorigenic capacity. |
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| The repeat long-term mouse study showed evidence of a tumorigenic response in the livers of the females at the highest dose level, however this was not considered to be biologically significant. |
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| So far, more than 2,500 components have been identified in the tobacco leaf and more than 3,900 components in tobacco smoke. Many of these have possible tumorigenic and carcinogenic effects. |
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| Cancer initiating cells are 1,000 times more tumorigenic than other cancer cells and are capable of self-renewals. |
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| Use of cell lines known to be tumorigenic or to possess abnormal karyology should be evaluated in terms of risk-benefit for each product application when the product contains cells or when not highly purified. |
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| Questionable carcinogen with experimental tumorigenic data. |
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| The outcome is presented here primarily as a basis for comparison with the tumorigenic potencies for cancer, to ensure that measures developed for this endpoint will be protective for other reported effects. |
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| The use of a ¿134.5 deficient strain of herpes simplex virus vector in the manufacture of a pharmaceutical composition for treating tumorigenic disease. |
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| This project is aimed at identifying SCs of the FT, evaluating their tumorigenic capacity and establishing a novel in-vitro human model for HGSOC development. |
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| These precancerous and fully tumorigenic models provide an ideal system to study the role of NRs in lung cancer pathogenesis including preneoplasia and tumor formation. |
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| When introduced into nude mice, transformed cells were tumorigenic. |
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| This model is further utilized to characterize local and systemic pathologic reactions, fate in the body and tumorigenic potential of engrafted cells. |
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