| You are right in saying that these drugs have potentially serious toxicities. |
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| Ninety-seven percent of all toxicities occurred within 60 days of starting the treatment. |
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| The combination of zalcitabine and didanosine or stavudine is not recommended because of overlapping toxicities. |
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| Selenium may have a protective effect against mercury and other heavy metal toxicities. |
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| Management of toxicities in the community requires close liaison with the hospital team, and severe toxicity requires immediate admission. |
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| Methotrexate and chlorambucil have been used as steroid-sparing agents, but have toxicities of their own. |
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| The toxicities observed following 6 months administration to dogs are considered proguanil related. |
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| Whereas diarrhea and fever are common toxicities associated with high-dose chemotherapy, it is likely that many cases of typhlitis go unrecognized. |
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| Specific toxicities were also potentiated by the concomitant administration of ketamine and nelarabine to all tested animals. |
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| Efforts were launched in 2008-2009 to establish an online global database on antiretroviral toxicities. |
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| Nucleoside analog associated mitochondrial toxicities such as lactic acidosis and severe hepatomegaly with steatosis. |
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| Co-administration of ezetimibe and statins did not result in any new toxicities. |
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| They worry about the long-term toxicities of the drugs they now take. |
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| Potentially fatal toxicities occur with off-label use of cancer drugs. |
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| Even different-sized granules of the same chemical can vary in their relative toxicities because of the differences in dissolution rates. |
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| By 1919 it was realized that exposure to sulfur mustard also produced very serious systemic toxicities. |
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| Dose modifications were based on haematologic and non-haematologic toxicities. |
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| This is especially so in Chinese medicine, because that's where you have very high toxicities. |
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| The issues of toxicities and insufficient virological and immunological potency are not being solved by current treatment strategies. |
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| Scientists are now looking for ways to combat these long term toxicities. |
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| Successful use of ART implies considerable efforts to maintain adherence to lifelong treatment, plus resources to monitor response, drug toxicities and interactions. |
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| These toxicities occur in patients treated longer than 10 days, in patients with abnormal renal function, in dehydrated patients, or in patients receiving medications with additive auditory toxicities. |
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| A wide spectrum of dermatologic toxicities has been associated with imatinib, among which a maculopapular rash is the most common event. |
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| This indicated that OA and CTN combination caused a severe hypoproteinaemia than individual OA and CTN toxicities. |
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| Many primary alcohols are metabolized into aldehydes then to carboxylic acids whose toxicities are similar to acetaldehyde and acetic acid. |
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| Infusion-related toxicities were typically grade 1 or 2 and were associated with pre-administration of Rituximab. |
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| Indeed, if we do a proper analysis of our blood, we would find thousands of different chemicals, most of them coming from natural sources but some of those would have toxicities comparable to the synthetics. |
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| This drug does not have a lot of the toxicities including insulin resistance that have tainted protease inhibitors so far. |
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| These toxicities can be particularly troubling, especially in the treatment of pediatric cancers. |
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| The NTP is looking into how to develop criteria for other organ and system toxicities, such as neurologic, gastroenterologic, cardio vascular, and pulmonary end points. |
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| The toxicities, mostly cytopenias, are manageable. |
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| Reported toxicities were predominantly haematologic. |
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| As anticipated, haematologic toxicities were relatively mild. |
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| The authors noted that all patients developed some hematologic toxicities and that non-hematologic toxicity was mild and manageable. |
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| Outside of the hematopoietic and stratified epithelia systems there is little clinical experience with the toxicities associated with infusion or transplantation of stem cells or their derivatives. |
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| The toxicities associated with aminoglycosides are severe and are sometimes irreversible, and the margin of safety between a toxic and a therapeutic dose is narrow. |
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| Phase 2 studies are designed primarily to assess the efficacy of the drug in the disease to be treated, although some data on adverse events or toxicities may also be collected. |
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| In more extreme cases, the toxicities can result in serious damage to organs such as the kidneys, the liver, and the ears and to the nervous system. |
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| Earlier-stage trials are of limited duration, and subsequent research can identify side effects, toxicities, drug interactions and overall tolerance that may only emerge over time. |
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| In view of the known toxicities of agents of this class, it would be prudent to proceed carefully in patients with known or suspected renal insufficiency or severe bone marrow impairment of any etiology. |
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| After numerous reports of Laetrile toxicities and little evidence of effectiveness, studies were carried out by the United States National Cancer Institute that failed to demonstrate any clinical anti-cancer effect. |
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| However, drug toxicities will always be preferable to inevitable death in the absence of drug treatment, particularly if concerns over toxicities prevent availablity of treatment in resource-poor settings. |
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| Salinity affected germination through osmatic pressure and toxicities of specific salts and nutritional imbalances. |
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| Use of estramustine in combination with other cytotoxic agents is not recommended due to the increased risk of clinically important toxicities. |
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| Other toxicities reported in conjunction with zalcitabine use include lactic acidosis, hepatic failure, oral ulcers, esophageal ulcers and congestive heart failure. |
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| Also, these studies didn't examine the enantiomers' toxicities. |
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| But there were other toxicities in favor of the Epzicom arm. |
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| The safety of bipolar TURP is enhanced by the use of normal saline eliminating the incidence of the metabolite toxicities and dilutional hyponatremia. |
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| We don't worry very much about the toxicities of lamivudine and emtricitabine any more except in patients who are chronically coinfected with hepatitis B virus. |
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| Maternal toxicities include spontaneous abortions, premature labor and delivery, premature rupture of membranes, placenta previa, and abruptio placentae. |
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| However, owing to their high toxicities, colchicine and thiocolchicine are still in preclinical trials to determine their potential anti-tumor activity. |
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| Toxicities of two herbicides and an algicide to mosquitofish Gambusia affinis. |
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