The double helix of DNA winds about individual nucleosomes, forming a superhelix. |
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Here we report the 3.0 Å crystal structure of unliganded Kapβ2, which consists of a superhelix of 20 HEAT repeats. |
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The inner surface of the superhelix exposes conserved residues of Cmr4 that we show are required for target-cleavage activity. |
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In fact, a wide range of structural proteins have coils in which two or three helices are wound around each other to form a left-handed superhelix conformation. |
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This USO repeat does not follow the rule of classical armadillo repeat proteins that form a right-handed superhelix. |
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Of course, this behavior can be attributed to deficiencies in the theory, but a more obvious explanation can be found in branching of the superhelix. |
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Protein-protein crosslinking enabled the localization of the BS-binding proteins p14 and U2AF65 within SF3b155's HEAT-repeat superhelix, which together with SF3b14b forms a composite RNA-binding platform. |
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