| The thermotropic phase behavior of egg sphingomyelin is complex reflecting the mixture of different molecular species. |
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| We have modeled sphingomyelin, the most common sphingolipid in mammalian cells, by means of molecular dynamics simulations. |
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| Cholesterol and sphingomyelin are thought to be the principal components of lipid rafts in cell and model membranes. |
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| The sphingomyelin content is also high in the central nervous system and in the spinal cord. |
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| In contrast, choline is essentially derived from the circulation, and only negligible amounts are incorporated into other lipids, such as sphingomyelin. |
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| If the enzyme ASM is absent or not functioning properly it will not break down sphingomyelin and will accumulate within the cell. |
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| These lysosomes are required to metabolize a special lipid, called sphingomyelin. |
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| Among the sphingolipids, only sphingomyelin, a phospholipid, is a major component of biological membranes. |
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| In this study, we have examined how the headgroup size and properties affect the membrane properties of sphingomyelin and interactions with cholesterol. |
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| Why excess sphingomyelin causes so much damage is not clear, said Dr. Edward Schuchman, a professor of human genetics at the Mount Sinai School of Medicine in Manhattan. |
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| Her brain, as well as other organs, needs the missing enzyme to break down sphingomyelin, but the enzyme itself probably cannot pass into the brain, researchers say. |
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| Another inheritable lipidosis is Niemann-Pick disease, in which lecithin and sphingomyelin accumulate in various body tissues, such as the spleen and the liver. |
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| In vivo, dysregulation of enzymatic conversion of the cell membrane phospholipid sphingomyelin to ceramide by SMase leads to a change in ceramide concentration. |
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