Crystal structures help to orientate the scissile bond in the enzyme complex structure. |
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We find, however, that the putative sodium ion binding site is near the scissile bond of PC activation. |
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Neighboring scaffolding residues like Arginines or Asparagine shape-up the inhibitory loop and favor the resynthesis of cleaved scissile bond. |
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Our data emphasize the importance of the 2′OH in the immediate vicinity of the scissile bond. |
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Caspase-specific substrate recognition appears to be determined by the substrate sequences adjacent to the scissile bond. |
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After a nucleophilic attack of a water molecule on the scissile phosphorous a water-proton is transferred to the O1P oxygen as the first step. |
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