| Administration of this drug with probenecid should be avoided as it has been found to inhibit the renal excretion of meropenem. |
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| This finding was confirmed by the lack of effect on the clearance of ceftobiprole when probenecid was co-administered. |
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| The concomitant use of TORADOL and probenecid is, therefore, contraindicated. |
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| Scientists found that a simple benzoic acid derivative called probenecid stops many drugs, including antibiotics, being removed from the blood by the kidneys. |
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| The concomitant use of ketorolac tromethamine and probenecid is also contraindicated. |
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| Interactions with coumarin, methotrexate, probenecid, sulfinpyrazone, spironolactone, furosemide and rifampicin can not be excluded. |
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| Probenecid: The concomitant use of probenecid with certain other quinolones has been reported to affect renal tubular secretion. |
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| Medications such as allopurinol and probenecid, which inhibit the synthesis of uric acid in the body, are used to treat recurrent acute attacks. |
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| The effect of probenecid on the elimination of ofloxacin has not been studied. |
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| Another drug, probenecid, helps the kidneys excrete uric acid. |
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| Cidofovir 80 mg weekly was given with probenecid on day 15 for 3 weeks when her creatinine level failed to improve. |
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| Co-administration of probenecid with intravenous acyclovir has been shown to increase the mean half-life and the area under the concentration-time curve. |
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| Sometimes this effect is used to advantage, as, for example, when probenecid is given with penicillin to decrease its removal and thereby increase its concentration in the blood. |
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| The drug probenecid, which can be given simultaneously, competes with penicillin at its secretory site and thus helps to raise the level of penicillin in the blood in the treatment of certain infections. |
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| The renal tubular secretions of cefazolin may be decreased when probenecid is used concurrently, resulting in increased and prolonged cefazolin blood levels. |
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| Benemid cannot be used in the patients with allergy to probenecid, uric acid kidney stones, just started acute gout attack, decreased white blood cells, anemia. |
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| Concomitant use of probenecid is not recommended, and may result in increased and prolonged blood levels of amoxicillin, but not of clavulanic acid. |
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| Note that probenecid is contraindicated in kidney disease and when a history of kidney stones is present. |
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| Alternative parenteral single-dose regimens for urogenital and anorectal gonorrhea include 500 mg ceftizoxime, 2 g cefoxitin with I g oral probenecid, or 500 mg cefotaxime. |
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| Probenecid is a uricosuric agent and an alternative to allopurinol. |
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| Probenecid is still useful, however, for certain infections requiring particularly high concentrations of penicillins. |
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| Probenecid administration should be accompanied by generous daily fluid intake as well as consideration of urine alkalinization to reduce stone risk. |
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