| The transformation of score values assigned to single cells resulted in a quantitative outcome measure for each proband. |
|
| A genetic basis to the disorder is borne out by risk increasing with genetic proximity to the proband. |
|
| If the proband has trisomy 21, the likelihood of a trisomy 21 pregnancy is minimally increased for family members other than the parents. |
|
| Furthermore, all these approaches are unable to handle trios with missing genotypic information on the proband and these families are typically excluded from the analysis. |
|
| If a proband was found to have at least two siblings with alcohol dependence, the family was recruited for the second stage of the study. |
|
| However, establishing a link between proband characteristics and psychiatric disorders in relatives would strengthen that suggestion. |
|
| It was also reported that the proband group had a higher rat e of academic problems, including suspension, drop out, expulsion, and having failed a grade. |
|
| Where possible, archived DNA from family members was tested with PCR, restriction endonuclease or sequence analysis for the putative change identified in the proband. |
|
| To facilitate the proband selection rates are set by the airport, which is at the expected passenger traffic to certain destinations and destination groups are based. |
|
| Review of the family history revealed that the proband was the third child born to nonconsanguineous parents, a 32-year-old father and a 27-year-old mother. |
|
| The proband was a 15-year-old female patient from Masuria in the northern part of Poland who had been suffering from photosensitivity since early childhood. |
|
