| Like all viruses, poxviruses co-opt various cellular molecules and processes to enter a cell, replicate and then spread to uninfected cells. |
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| He followed this achievement by showing how poxviruses express their genes and replicate their DNA in host cells. |
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| The main platform used by Transgene is based on viral vectors, specifically poxviruses. |
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| Unlike other DNA-viruses, poxviruses appear to develop entirely within the cytoplasm of affected cells. |
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| Because poxviruses replicate in the cytoplasm, it is easy to see all the processes, or arms, of each cell. |
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| Bacteriophage is a tailed, double-stranded DNA virus that serves as an important model for assembly of large DNA viruses such as herpes and poxviruses. |
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| The life cycle of poxviruses is complicated by having multiple infectious forms, with differing mechanisms of cell entry. |
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| Viral vehicles with the capacity to serve as vaccine vectors are retroviruses, poxviruses, adenoviruses, adenoassociated viruses, herpesviruses, and alphaviruses. |
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| Among the poxviruses are several species of orthopox-viruses that are pathogenic to humans, including monkeypox virus and variola virus. |
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| Microscopically, poxviruses produce characteristic cytoplasmic inclusions, the most important of which are known as Guarnieri bodies, and are the sites of viral replication. |
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| The new molecule can block the action of numerous virus including HIV-1, influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses and flaviviruses. |
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| Poxviruses are structurally more complex than simple bacteria, despite their close resemblance. |
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| Poxviruses are unique among DNA viruses in that they replicate in the cytoplasm of the cell rather than in the nucleus. |
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| Poxviruses replicate in the host cytoplasm using a processive polymerase composed of several viral proteins. |
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| Poxviruses are among the most dangerous viruses for the human species. |
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| Poxviruses have evolved a wide-spectrum of open-reading frames encoding immunoregulators which bind host proteins and disrupt the antiviral immune response. |
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