How to use placebo in a sentence

Looking for sentences and phrases with the word placebo? Here are some examples.

Sentence Examples These data imply that kava extract is superior to placebo as a symptomatic treatment of anxiety. Experiments on animals have proved beyond doubt that even a placebo can cure by improving the immunochemistry of the body. These trials compared SSRIs with placebo in adults with depression and other clinical conditions. There were no significant differences between the soy and placebo groups in the number of hot flashes or hot flash scores. A randomized, placebo-controlled, double-blind trial found that Panax ginseng showed no benefit over placebo on hot flash scores. We undertook separate analyses of micronised oral progesterone and progesterone pessaries or suppositories versus placebo. The pressure pain threshold was higher after dronabinol treatment than after placebo treatment. The first section, on placebo effects, provides an accurate overview of current scientific thought. It apparently did not occur to Gary that maybe he had tapped into the placebo effect or the power of suggestion. Any effects of rhino horn are almost certainly placebo effects, of which scarcity, improbability, and high cost play a part. There was no detectable difference in cold duration or symptom severity between the echinacea and placebo groups. A placebo is a non-active 'medication' that a patient believes to be a drug of some kind. The placebo induced a significant release of dopamine from the damaged striatal neurons, detectable by positron emission tomography. A Hawthorne effect could occur in both acupuncture and placebo treatment groups because they were studied. Seven children died from illness or injury without oedema, three in the antioxidant supplement group and four in the placebo group. No significant differences were observed between the homeopathic group, a placebo group, and patients who were given nothing at all. A funnel plot showed noticeable asymmetry in the 11 placebo controlled trials. Most of these studied different regimens rather than comparing cryotherapy with other treatments or placebo. If a curative effect doesn't show up in double-blind tests, then you're mainly talking about the placebo effect, in any case. Following a two-week placebo or vitamin capsule lead-in period, a randomized crossover treatment paradigm was utilized. Show More Sentences The study was a randomised double blind placebo controlled crossover trial. The subjects received three consecutive weeks each of MPH and placebo in random order and under blind conditions. Acupuncture and related therapies such as acupressure have been found to be no more effective than placebo therapies. For example, your question might be whether it is ethical for nurses to administer placebo medication. Also, the high placebo response rate made finding a statistical difference almost impossible. With a high rate of spontaneous cure of the illness, such studies need a large number of subjects to balance the expected high placebo reactors. Whatever the treatment, the placebo effect is always present, whether intended or unintended. The studies were usually withdrawal studies contrasting withdrawal to placebo after a symptom-free period. Since the placebo effect may depend on the patient's conscious or subconscious attitudes to treatment, this might be thought relevant. Until the allocations are revealed at the end of the trials, neither patients nor doctors know who is getting the real drug and who the placebo. The interpretation is that acupuncture needling is of benefit in neck pain and that this is not attributable to a placebo effect. In the first placebo controlled trial conducted in rapid cycling disorder, lamotrigine improved the overall relapse rate. Several recent double-blind trials have found that this herb has no advantage over placebo for treating colds. In both studies, bright light was superior to the placebo condition in producing clinical remissions. Administering a placebo is an act of deception that is ethically problematic. An indication that regression to the mean is occurring is that patients with the worst clinical scores have the biggest placebo effect. Research was an important component of the course, and lectures on research methods and the placebo effect were included. The incidence also explains the powerful placebo effect of some treatments. All patients began a reduced-energy diet at the onset of the placebo lead-in period and followed the diet for the first 52 weeks. Before and after each administration of salmeterol or placebo, patients were assessed for heart rate, respirations, and breath sounds. Show More Sentences Even when so-called placebo responders are dropped from a study, a good proportion of the remaining patients respond to placebos anyway. However, in similar coronary artery studies, antiplatelet treatment has no effect on restenosis compared with placebo. Only two of the 12 reacted to the large dose of MSG but not the placebo in the retest. This raises the question of whether treatment causes a placebo effect, perhaps because of the extra time spent with patients. There was also a 1.7-times higher chance of cure in the fluticasone group than in the placebo group. In addition, the placebo effect is even higher when the placebo has some antihistamine effect. Two percent of patients in the Neulasta arm required intravenous anti-infectives versus 10 percent of patients in the placebo arm. This study was observational, and intravenous treatment by enthusiastic investigators has a considerable placebo effect. This study of 56 symptomatic women found evening primrose oil to be no more effective than placebo in controlling vasomotor symptoms. In three small studies, men taking nettle root reported slightly better urine flow than men who were given a placebo. The act of rubbing it in may well be soothing, but in four placebo controlled trials arnica was found to be no more effective than the placebo. All placebo controlled trials were positive and all comparative trials indicated equivalence with other active therapies. Most health care professionals view homeopathy as relying on the placebo effect to produce results. All of health care before that was the power of the placebo effect, and the charismatic health care provider. However, inactive agents are a poor placebo for an easily discriminable drug such as nicotine. Adverse side effects included constipation, nausea, asthenia, and dizziness in 6.2 per cent more patients than those taking placebo. Interestingly, giving the subjects something that blocks the effects of the original drug resulted in the effects of the placebo being lost. No differences in distribution of the bacteria were found between the spray and placebo groups. Overall, there is much to learn about placebo substances and the placebo effect. As far as the placebo issue is concerned I believe they are using the Food and Drug Administration as an Aunt Sally. Show More Sentences This implies that our findings perhaps cannot be explained purely in terms of the placebo effect. The most well known example of generalized expectancies is the placebo effect. Therefore, we cannot be certain whether our data show a specific effect of magnets, a placebo effect, or both. The main disadvantage of an open trial is the possibility of a placebo effect favouring antibiotics. In medicine we have to add double blind testing, because both physician and patient can be misled by the placebo effect of hope. One method would be to test the current dosing regimen against shorter, delayed, or less potent regimens rather than placebo. With the alcohol flavor masking taste, there were no discernible differences between the study medication and placebo. Half of the group added the odorless pheromone to their preferred perfume, the other half added a placebo. That one doesn't get answered as often as it should, because the FDA generally only requires testing against placebo. Researchers from Philadelphia gave a single intravenous dose of secretin versus placebo in 61 children with autistic spectrum disorder. Thirty-eight percent of patients responded to the placebo, and 52 percent to the medicines. The eight patients treated with placebo from all dose groups were combined for the purpose of summaries and analyses. After one year, patients in the placebo group had significantly more knee surgeries than those in the treatment group. The revised declaration also calls for new treatments to be tested against the current best treatment rather than placebo. This finding was confirmed by a study that randomised 112 patients to treatment or placebo. It was used to investigate the different effects of ultramolecular potencies compared with placebo rather than pragmatic homoeopathy. The pain experienced by patients in both the placebo and cold gel groups was at the same level at the beginning of this study. For example, during the first year, patients receiving orlistat lost more weight than patients receiving a placebo. They found a significant improvement of symptoms compared to patients taking a placebo. Lightheadedness was reported by two patients in the placebo group, but no adverse effects were reported in the treatment group. Show More Sentences In the first phase, more patients are randomised to placebo than to active treatment. Sensitivity analysis excluding those patients who received the placebo tablet did not change our conclusions. Following up the placebo arm of a randomised trial can be a good way of tracking the course of benign diseases. Our study was designed as a prospective, randomised, double blind, placebo controlled trial. Such traditions generate belief, allowing future rituals to produce placebo effects. Other studies comparing ephedra with placebo or herbs containing caffeine yielded similar results. He found that when a subject took glucose, they performed no better than when were given a placebo. And trust is a priceless asset in medicine, where a placebo can work wonders. Clomipramine was equal to desipramine and both tricyclic agents were superior to placebo for amelioration of hyperactivity. The point is that all therapeutic practices, all therapeutic interactions have a placebo component. The researchers gave half the children daily co-trimoxazole, the other half received a placebo. Patients could also be prescribed a placebo as part of this research, but the nutrition and exercise counseling is worth a lot on its own. All patients received placebo via the inhaler and were instructed on the proper technique for using this device. Most doctors are aware of placebos and the placebo effect, but probably few have given the subject any serious thought. A practitioner who administers a placebo wants to benefit the patient by making the patient believe that he is receiving an active treatment. The placebo effect is then defined as the difference in effect in the patients receiving placebo compared with those receiving no treatment. Cough was the only side effect that was more prevalent in this group than in the placebo group. Complement properdin increased by 21 percent compared to the placebo group. The drug defaulter, just like the placebo reactor is not a consistent or readily identified person. Is it unethical for a doctor to knowingly prescribe a placebo without informing the patient? Show More Sentences The phenothiazines prochlorperazine and chlorpromazine have been shown to reduce nausea and vomiting of pregnancy compared with placebo. Half the women received magnesium sulfate by injection or infusion in the hospital over about 24 hours, and the rest got a placebo. Six studies showed a significant benefit of probiotic treatment compared with placebo. Participants were randomly given influenza vaccine and placebo injections, at least five days apart. The placebo contained ferrous sulphate 120 mg and calcium phosphate 240 mg. The double-blind placebo trials use inactive agents to control for placebo effects. They all drank a triple espresso, a decaf triple espresso and were given intravenous caffeine and a placebo. Significantly higher patient satisfaction was reported in the botulinum toxin type A group than the placebo group. Korean researchers had 45 impotent men take either 900 mg of Korean red ginseng or a placebo three times daily. In the vitamin group, 12.5 per cent neonates had birth weight below 2.5 kg compared to 15.6 per cent in the placebo group. The fact that a particular respondent uses a placebo in a clinical context is not likely to be misremembered, however, even if the frequency is misjudged. A more extensive study involving 86 CD patients examined the effect of 50,000 IU vitamin A acetate twice daily or placebo for an average of 14.1 months. Those who had received the actual drug reported better levels of self-satisfaction than the unfortunates who just got the placebo. Of the tricyclic antidepressants, amitriptyline appears to be the most efficacious in the treatment of diabetic neuropathy when compared to placebo. The question exists as to why both the lidocaine and the placebo saline solution would have an inhibitory effect on muscle-firing characteristics. The 244 patients who remained in the study after the run-in period were randomized to continue receiving the inhaled corticosteroid or to receive placebo. In one experiment that compared zinc to a placebo, participants who sucked on zinc lozenges every couple of hours found that the length of their cold was cut in half. Live, attenuated influenza virus vaccine and placebo were administered as an intranasal spray in a single dose between mid-September and mid-November. Therefore, we evaluated the effects of the inhalation of lidocaine, salbutamol, lidocaine and salbutamol combined, and placebo on an inhalational histamine challenge. Some women find colposcopy very painful while others hardly notice it, according to a clinical trial testing topical benzocaine and ibuprofen against placebo. Show More Sentences Following a 2-week, single-blind placebo washout phase, 12 autistic subjects completed a 10-week, double-blind, crossover comparison of clomipramine and placebo. In clinical trials held in April, climbers taking the supplement were half as likely to experience acute mountain sickness as those taking a placebo. Some of the patients in the control group who did not achieve resolution of the wart following the placebo injection were unblinded and given Candida antigen injections. It was shown in a multi-centre double-blind, placebo-controlled trial of 133 patients that a non-acidic form of vitamin C significantly reduced pain compared to a placebo. He concludes that the value of zinc in persons with common cold symptoms remains unestablished because of blinding problems in comparing oral zinc preparations with placebo. After the surgery he discovered that he had simply drunk fruit juice with added sugar and he had been given a placebo. Half were given the cream and the rest a non-active placebo. But again it would be inappropriate and unethical to use a placebo when the consequences of doing so would subject someone to the risk of serious or irreversible harm. Although people commonly think of a placebo as a component of pharmacotherapy, the placebo effect may also exert powerful effects on surgical outcomes. This requirement may conflict with the Declaration of Helsinki, which deems it unethical to give patients a placebo if an evidence based treatment is available. In the first week, three patients in the fusidic acid cream group and eight patients in the placebo group did not comply with the treatment protocol. The practice of testing new medicines against placebo, rather than against the best treatment available, has contributed to a general lack of knowledge. There is some debate as to whether an argon suit inflation system keeps you warm, or merely acts as a placebo i.e. making you believe that you're warmer! This may be attributed to a high placebo effect and the large number of poorly controlled trials in women without a pretrial diagnosis of premenstrual syndrome. The placebo effect is a real problem in some clinical trials. In fact, however, the placebo effect itself varies greatly, not only with the condition being treated but also with the mental outlook of the patient. They were randomly given 600 international units of vitamin E or placebo. Nursing-facility residents who consumed 200 international units of vitamin E daily for 1 year were less likely to get the sniffles than those who took a placebo. This study reported no significant difference in exacerbation rates between iodinated glycerol and placebo, but the summary statistics were not available. The study was a double-blind, randomized, crossover study in which the subjects used identical inhalers containing placebo or salbutamol for 6 weeks. Show More Sentences A recent large multicentre randomised controlled trial of botulinum toxin for glabellar lines showed a significant reduction in the lines compared with placebo. O'Kroy and the team of researchers found no significant differences between the placebo and the active nasal dilator regarding the total work of breathing. One trial of the expectorant guaifenesin reported a significant benefit over placebo, but a second trial found no differences between the treated and placebo groups. The scientists randomly assigned 18,882 men to receive a daily finasteride pill or a placebo. The study was 8 weeks in duration during which time patients were administered either LUNESTA with fluoxetine or placebo with fluoxetine. The patients were randomized to also receive 10-40 mg daily of the angiotensin-converting enzyme inhibitor lisinopril or placebo. The two largest and longest studies gave 921 men and women with type 1 or type 2 diabetes 600 mg of lipoic acid or a placebo every day. Forty-eight children were randomly assigned to receive, in double-blind fashion, 200 mg per day of riboflavin or placebo for 12 weeks. There the placebo, the office for the dead, was sung, and a vigil kept throughout the night. There was non significant improvement in the rhonchi in placebo group but there was significant improvement in the rhonchi in test drug group. Half received 200 mg of aspirin right before surgery, while half received a placebo. The Top 5 most likely to cause somnolence, compared with placebo, are fluvoxamine, mirtazapine, reboxetine, paroxetine, and desvenlafaxine. For this reason, critics argue that therapies that rely on the placebo effect to define success are very dangerous. Patients taking chondroitin sulfate showed no joint changes, while those on placebo showed significant joint space narrowing. Lenvatinib versus placebo in radioiodine refractory differentiated thyroid cancer. Mice were injected intratibially with mouse OS cells and then randomized to receive placebo or doxorubicin. The intervention group received 150mg oral levamisole while the control group took a placebo tablet on two consecutive days weekly. Impressive results were also seen when alginates were experimentally compared to antacids and placebo. Two groups were administered one of two antihypertensive medications, losartan or enalapril, and the last group, a placebo. The patients were randomly divided into two groups to receive homoeopathically potentised Ignatia 30C or placebo. Show More Sentences They were randomized to dextromethorphan hydrobromide and quinidine sulfate or placebo for 10 weeks. They performed a double-blind, crossover designed trial versus placebo in 40 overweight subjects with mixed hyperlipidaemia. During the reviews, the board evaluated safety data of patients treated with the drug as compared to those receiving placebo. First, the volunteers underwent a 16-day phase-in period to gradually reach the maximal level of daily potassium bicarbonate or placebo capsules. Focal electroretinograms and clinical findings were recorded at baseline and after 3 months of saffron or placebo supplementation. John's wort to be more effective than placebo and as effective as imipramine. Patients received 20-40 mg paroxetine once daily, 200-300 mg imipramine once daily, or placebo. There was one lost to follow up in both groups and one withdrawal in placebo group because of punctiform hemorrhage in the brain. Iloperidone was also associated with a favorable profile on the Extrapyramidal Symptoms Rating Scale versus placebo. All patients received the ACE inhibitor perindoprill and the diuretic indapamide or placebo for blood pressure control. The investigators performed electrocardiograms on the volunteers before taking the drug or placebo and again after 1, 3, and 5 hours. A RCT investigated the effects of twice weekly NB-UVB and 250mg oral polypodium leucotomos extract versus NB-UVB and placebo. The first, by Kruesi and colleagues, compared clomipramine versus desipramine, with a two-week, single-blind placebo lead in. BioElectronics Corporation has completed a randomized, placebo controlled crossover trial on plantar fasciitis using ActiPatch. They also excluded trials that mentioned a placebo washout period, a common device to weed out patients susceptible to placebo effects. Surprisingly, rigorous research of placebo effects has only gained momentum in the past decade. In discussions of medical therapies, the focus is generally on the effectiveness of medications and not on placebo effects. This underscores the importance of placebo effects in the development of new drugs. Even within the realm of medicine, the psychological is as important as the physical, and the placebo effect not to be sniffed at. Whilst this proposal is at face value counter-intuitive, it is not inconsistent with recent findings relating to the placebo effect in medicine. Show More Sentences Joe does more than simply explore the history and the physiology of the placebo effect. There was a modest but significant worsening at endpoint in akathisia symptoms for lurasidone versus placebo. Researchers randomly assigned 49 healthy people aged 55 to 87 to take either zinc gluconate or a placebo. The authors hypothesized that pain ratings after exercise would be lower in the ginger group compared to placebo subjects. Study participants will be randomized equally to receive either NeuroVax or placebo intramuscularly in the deltoid muscle every four weeks. Secondary outcomes included the palatability of the true and placebo tinctures. One trial found more effective pain relief from an 8-day course of Norgesic than placebo. They were given either one daily tablet of 2mg oestradiol valerate or a placebo for two years. Blinding may have been suboptimal due to the nonidentical appearance of the omeprazole placebo control capsule. Subjects report the physiological arousals induced by adrenaline and placebo differently. Women on alprazolam had significantly reduced levels of anxiety compared with those on placebo during the first flight. Eleven patients in misoprostol group and 7 in placebo group were nulliparous. A study of over 200 people with osteoarthritis took either 1,500 mg of glucosamine sulfate each day for three years or a placebo. Some compared one statin to another, while others compared a statin to an inactive placebo, which is often called a sugar pill or dummy pill. The participants who received the bupropion were twice as likely to be abstinent as those receiving placebo. The placebo and nocebo effects are widely chronicled in psychology texts and studies. Bowling proposes that placebo and nocebo responses are an intrinsic part of therapy outcomes. This may be the underlying mechanism of placebo and nocebo effects of medications and other therapies. Penile tumescence and the ability for sexual intercourse significantly improved for patients on Tadalafil once a day versus those on placebo. Among these patients, those in the clopidogrel group reported 142 adverse events, and those in the placebo group reported 119 adverse events. Show More Sentences A lower level of the transaminases associated with liver damage in the MetabolAid group than in the placebo group. Researchers gave more than 14,600 men aged 50 or older in the Physicians' Health Study either a daily multivitamin for seniors or a placebo. A total of 57 were randomized to either chamomile extract or placebo for 8 weeks. In the placebo condition, heart rate decreased consistently from presmoking levels. During the study, men received either an inactive placebo or avanafil at a dose of 50 milligrams, 100 milligrams, or 200 milligrams. In addition, calcipotriol ointment and placebo ointment were applied to each side of the body. Subjects were randomized to either BTX-A or placebo with the goal of understanding the average number micturitions at four weeks post-treatment. The herbal supplement black cohosh, taken for relief of menopausal hot flashes, doesn't work any better than a placebo, a study finds. The first analysis consisted of two studies assessing 704 subjects with NERD who received esomeprazole 20 mg, esomeprazole 40 mg, or placebo. Mean serum bile acid levels and pruritus at the end of the study were lower in both SHP625 and placebo treated groups as compared to baseline. She presented a study in which eplivanserin 's effects upon cognitive and psychomotor performance were compared to those of flurazepam and placebo in 24 healthy subjects. The placebo capsules contained 350mg of freeze dried Urtica dioca folia as this has no known effect on the CNS, yet is similar in appearance and smell to skullcap. All the standards and tests samples were prepared using sterile normal saline solution which also, served as placebo in the different experiments. The primary endpoint of the trial will be the relative mean change in the Orthostatic Hypotension Questionnaire composite score between Northera and placebo. At the end of treatment, albumin retention significantly decreased in the group treated with the flavonoid fraction in contrast with the placebo group. Acetaminophen taken regularly or as required was no better than placebo in improving time to recovery in patients with acute low back pain, Australian research shows. In a single blind randomised control pilot study, curcuminoids or placebo was administered orally, 2 grams twice daily to a cohort of 26 MGUS patients. In the first protocol ginger and placebo were given two days before the onset of the menstrual period and continued through the first three days of the menstrual period. Ninety-six patients with melasma were randomly assigned to apply, in double-blind fashion, silymarin cream or placebo cream to the affected areas twice a day for 4 weeks. The EOE treated group showed a significant improvement compared to the placebo group in all the subjective and objective parameters tested with no reports of adverse events. Show More Sentences The placebo effect has a dark twin called the nocebo effect. Establishing a link between certain genes and the placebo effect is in its infancy, the researchers say online April 13 in Trends in Molecular Medicine. In the French GuidAge study, groups of elderly people with memory complaints were randomly assigned 240 milligrams per day of ginkgo extract, or a placebo, to be taken daily. On comparison of the anticatarrhal effect of placebo versus test drug the efficacy of placebo was non significant while the efficacy of the test drug was highly significant. Several earlier pilot studies assessed the ability of hawthorn to help improve exercise tolerance in people with NYHA class II cardiac insufficiency compared to placebo. Patients were randomised to ginger root powder capsules or placebo capsules as an additional antiemetic to ondensetron and dexamethasone in a double blind design. Another study of 42 patients with cancer showed improvement in depressive symptoms prior to improvement in physical symptoms with trimipramine compared with placebo. In a third analysis the improvement of dyspnea, as measured by the Transition Dyspnea Index, was shown in COPD patients, compared to tiotropium, olodaterol and placebo. In brief, the PEACE trial was a double-blind, phase III trial that randomized patients with stable CAD and preserved left ventricular function to trandolapril vs placebo. Lewith GT, Machin D A randomised trial to evaluate the effect of infra-red stimulation of local trigger points, versus placebo, on the pain caused by cervical osteoarthrosis. She's curious about the extremely high placebo response rate and wonders whether some members of that group might have been taking glucosamine and chondroitin on their own. Because compression clothing is a valid treatment for some ailments, the clothing may have that benefit, but the added copper may have no benefit beyond a placebo effect. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata in patients with uncomplicated upper respiratory tract infection. The mice were assigned to treatment with a placebo, the aromatase inhibitor anastrozole, the antiestrogen fulvestrant or a combination of anastrozole and fulvestrant. Likewise, neuroimaging studies show that placebo treatment activates specific brain structures such as the prefrontal cortex and the rostral anterior cingulate cortex. Based on a consumer perception study, Fision Hydrate left skin instantly feeling smoother and better moisturized when compared to a commercial lotion and the placebo. The placebo contained 500 mg xylitol and other nonplant ingredients. Examples from Classical Literature It is a milder form of this same method to give what the learned faculty term a placebo. We'll call this the placebo criticism and will come back to it, too, in a moment. The placebo effect has become increasingly interesting to psychological as well as medical researchers. This is a last phase of the metaphysical polity, and is only a kind of placebo. Extract and placebo capsules were indistinguishably packaged and labeled with a subject number. One group drank only caffeinated black tea, while the other group drank a caffeinated placebo that had an identical taste. The phase 3 study was unblinded midway, allowing patients receiving the placebo to instead take the drug because of the favorable results. Researchers assign patients by chance either to a group taking the new treatment or to a group taking a standard treatment or a placebo. Persons who had taken a placebo or only one medication, on the other hand, behaved goal-directed and showed a satiating effect. There are continued post hoc analyses between the women who received oestrogen plus progesterone and those allocated to placebo. In clinical trials, treatment-emergent EPS assessed by formal rating scales occurred at incidences comparable to placebo. Choosers were those who chose caffeine over placebo in the majority of 10 choice session and Nonchoosers chose placebo over caffeine in the majority of choice sessions. Find more words! 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What is the opposite of placebo? Words that rhyme with placebo What is the plural of placebo? What is the adjective for placebo? What is the noun for placebo? Translations for placebo Use our Sentence Generator Nearby Words place an order placeable Place place placatory placation placebo effect placebos placed placeholder placeholders placekicker 7-letter Words Starting With p pl pla plac place placeb