Abuse of combination analgesics containing phenacetin, antipyrine and caffeine have been associated with urinary tract tumors. |
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Because of incidences of nephrotoxicity when taken over long periods, phenacetin is no longer available in the U.S. Found in two products. |
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For phenacetin, sufficient rat and human pharmacokinetic data is available to estimate that a relative systemic exposure ratio of at least 15 is necessary to produce positive findings in a rat carcinogenicity study. |
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Paracetamol was first seriously marketed in the 1950s as an alternative to the popular painkiller phenacetin, which was very good for headaches but had a tendency to give you kidney cancer. |
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Owing to its structural relationship both to phenacetin, the aminophenols and salicylates, 5-ASA was included in a series of compounds studied following identification of antipyretic-analgesic nephropathy in humans. |
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Phenacetin was used as an analgesic and antipyretic drug until 1983 when it was removed from the market because it can induce nephropathy and cancer. |
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Anxious to hide its real identity, they sold it as Antifebrine.Mindful of the successful branding of Antifebrine, they marketed this as Phenacetin. |
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