| Pharmacologic agents with known pharmacokinetic and pharmacodynamic properties and demonstrated efficacy in neonates should be used. |
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| Concentrations used in our experiments were similar to those found at the plasmatic level in pharmacokinetic studies on humans. |
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| Despite the pharmacokinetic and pharmacodynamic differences among various beta blockers, they have similar clinical antihypertensive efficacy. |
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| The concept of ethnic group differences in pharmacokinetic responses is far from new in the clinical pharmacology literature. |
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| The newer fluoroquinolone antibiotics also have improved pharmacokinetic parameters compared with the original quinolones. |
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| Also, bronchodilators may demonstrate different pharmacodynamic and pharmacokinetic characteristics during an acute exacerbation of asthma. |
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| Investigators have examined the pharmacokinetic parameters of menthol, the main component of peppermint oil. |
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| Complete pharmacokinetic data are not available in pediatric renal allograft patients. |
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| The first human pharmacokinetic study, for which Ambrilia has obtained the equivalent of an investigational new drug in Canada, is now ongoing. |
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| This software of pharmacokinetic is conceived for the analysis of the kinetics of fixed substances in a nonlinear way on plasmatic proteins. |
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| Some pharmacokinetic properties and principles apply to all inhalants. |
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| The Phase III Study collected blood samples for pharmacokinetic analysis and leukocyte enzyme uptake. |
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| Clinical pharmacokinetic data indicate that urinary elimination of bexarotene and its metabolites is a minor excretory pathway for bexarotene. |
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| The pharmacokinetic profile of HES is complex and largely dependent on its molar substitution as well as its molecular weight. |
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| The use of sugar derivatives as prosthetic group would improve bioavailability and pharmacokinetic properties of peptides. |
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| The pharmacokinetic parameters of cilazaprilat are not altered in the presence of increasing doses of the hydrochlorothiazide component. |
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| The pharmacokinetic profiles, or the dispositions in body tissues and fluids, have been well established for most of these substances. |
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| In addition, antibody development was specifically monitored in efficacy, toxicity and pharmacokinetic studies. |
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| Testing in a small number of healthy volunteers to determine safety, dose tolerance and pharmacokinetic properties of a product. |
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| We are currently conducting pharmacokinetic studies on PPL-100 and other preclinical work on this compound is nearing completion. |
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| Population pharmacokinetic data showed there is no independent effect of age on the pharmacokinetics of doripenem. |
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| Once new drug candidates are identified, their pharmacokinetic and pharmaceutical properties are fully characterized. |
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| In a general item, JECFA stressed the importance of pharmacokinetic studies for assessing the safety of food additives and contaminants. |
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| These are notably regulatory studies of toxicology and safety pharmacology, as well as pharmacokinetic studies. |
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| For example, in order to understand the pharmacokinetic effects of a calmative agent, information is needed on how the drug has access to the brain. |
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| Our application was supported by data from a comprehensive global clinical program incorporating 11 pharmacokinetic studies and five Phase III clinical studies. |
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| A single dose pharmacokinetic study of insulin aspart in 18 subjects with type 1 diabetes and with renal function ranging from normal to severely impaired was performed. |
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| Soon after the introduction of PIs it was recognised that co-administration with ritonavir improved their pharmacokinetic profile. |
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| These studies are designed to determine the pharmacological and pharmacokinetic profile of the drug and to assess the adverse effects associated with increasing drug doses. |
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| For phenacetin, sufficient rat and human pharmacokinetic data is available to estimate that a relative systemic exposure ratio of at least 15 is necessary to produce positive findings in a rat carcinogenicity study. |
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| Interspecies pharmacokinetic scaling allometric principles and applications. |
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| Herbal medicines have pharmacokinetic and pharmacodynamic interactions with conventional drugs. |
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| Salvage drugs with poor pharmacokinetic, pharmacological or toxicity properties when formulated as enterics. |
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| Because of the similar pharmacokinetic profiles, we presume that the effects of generic mirtazapines are similar to those of branded mirtazapine. |
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| No pharmacokinetic data are available in children. |
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| The overall population pharmacokinetic analyses demonstrated no interactions between anidulafungin and concomitant medications known to be metabolic substrates, inhibitors, or inducers of cytochrome P450 isoenzymes. |
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| The supplementary information in the Retrovirology article reports successful toxicology and pharmacokinetic studies. |
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| With regard to the middle ear cleft, direct pharmacokinetic studies of the mastoid and eustachian tube have not been performed. |
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| In summary, the pharmacokinetic data suggest that oral chlorambucil undergoes rapid gastrointestinal absorption and plasma clearance and that it is almost completely metabolized, having extremely low urinary excretion. |
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| In this study, HPLC and radioactive tracer assays were performed to determine pharmacokinetic, tissue distribution and excretion of GS-Rd in rodents. |
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| Aranesp has a unique pharmacokinetic profile compared to conventional rHu-EPO molecules, which means it can be administered less frequently than other erythropoietins. |
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| A phase 1 dose-finding and pharmacokinetic study of subcutaneous semisynthetic homoharringtonine in patients with advanced acute myeloid leukaemia. |
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| Chapter 9 discussed LC-MS as a powerful tool in dereplication of known natural products as well as in quality control of herbal products and in pharmacokinetic studies. |
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| Comparative pharmacokinetic study of paeoniflorin after oral administration of pure paeoniflorin, extract of Cortex Moutan and Shuang-Dan prescription to rats. |
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| Pharmacokinetic and bioavailability studies are an essential need to determine the exact pharmacological action of phytopharmaceuticals, but still unsufficient data do exist. |
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