| The progenitors of osteoclasts are from the hematopoietic cell line and the osteoblasts originate from the marrow stroma. |
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| They activate mature osteoclasts indirectly through osteoblasts, inhibit osteoclast cell death, and stimulate osteoclast progenitor formation. |
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| Williams also showed that genistein decreased acid secretion by osteoclasts, thus decreasing bone dissolution. |
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| The rate at which cells called osteoclasts break down bone is slowed, and the production of new bone increases. |
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| Vitamin D indirectly stimulates osteoclasts to resorb bone and is necessary for the intestinal absorption of calcium. |
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| Calcitonin is the only hormone that interacts directly on osteoclasts, which have a receptor for it. |
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| Histologically, this is associated with a decreased number of osteoclasts and an apparent decrease in their resorptive activity. |
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| On the other hand, osteoclasts derived from the hemopoietic cells are responsible for bone resorption. |
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| Metastatic tumour cells secrete paracrine factors which stimulate neighbouring osteoclasts to resorb bone. |
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| In addition, production of substances that activate the cells that resorb bone called osteoclasts is increased. |
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| A pH gradient across the ruffled membrane is the consequence of active transport mechanisms by the osteoclasts. |
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| The osteoclasts in turn release hydrochloric acid and enzymes into the mineralized bone and release calcium and phosphorus into the circulation. |
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| The aim of treatment with bisphosphonates is to suppress the excessive activity of the osteoclasts. |
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| Hereditary disease of the osteoclasts, the cells which break down bone substance. |
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| Bisphosphonates inhibit both the breakdown of bone by osteoclasts and the formation of new osteoclasts. |
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| Two types of cells make this process happen: osteoclasts, which break down bone and osteoblasts, which build it. |
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| The primary action of calcitonin is on bone, and in that tissue it is the osteoclasts which have most consistently been shown to be affected. |
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| This natural and necessary surface-bound molecule activates osteoclasts, cells involved in bone resorption. |
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| Note the presence of numerous osteoclasts lining the bone trabeculae. |
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| A few multinucleated cells were identified that were thought to be either multinucleated macrophages or normal osteoclasts. |
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| By preventing removal of bone without actually killing osteoclasts, the drug could trigger net formation of new bone and at the same time offer physicians greater flexibility as a complement to bisphosphonates. |
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| Odanacatib selectively inhibits cathepsin K, the major enzyme in osteoclasts that is responsible for the breakdown of existing bone tissue. |
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| Excited by this possibility, members of the team systematically changed the acidity of the culture medium and observed that acidification consistently activated a transcription factor called NFAT within osteoclasts. |
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| However, the major metabolic activity in bone is carried out by osteoblasts, which generate the protein matrix, and osteoclasts, which are large multinucleated cells that digest and dissolve the components of bone. |
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| An in vitro method for differentiating human osteoclast precursor cells into human osteoclasts, which comprises culturing the osteoclast precursor cells in the absence of accessory cells. |
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| The osteoclasts are the mediators of the continuous destruction of bone. |
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| Tildren has been launched to regulate osteoclasts in areas of excessive activity. |
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| Thus, when there is inadequate dietary calcium to satisfy the body's calcium needs, both PTH and calcitrial work in concert on osteoblasts to recruit precursors of osteoclasts to become mature osteoclasts. |
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| Odanacatib inhibits cathepsin K, the primary protease in osteoclasts that breaks down bone collagen during bone resorption. |
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| Histologically, osteoclasts around bony trabeculae are present, indicating active bony resorption at the revascularization front. |
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| The mechanism of action takes advantage of osteoclasts' voracious appetite: as osteoclasts dig pits in bone, they bind to bisphosphonate-coated crystals on the bone surface. |
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| In most cases, the bone at the base is destroyed by osteoclasts and the antlers fall off at some point. |
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| MicroRNAs can reduce that forced labor by inhibiting osteoclast proteins and thus limiting the number of osteoclasts present. |
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| Osteoblasts and osteocytes are derived from osteoprogenitor cells, but osteoclasts are derived from the same cells that differentiate to form macrophages and monocytes. |
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| Osteoblasts can also be stimulated to increase bone mass through increased secretion of osteoid and by inhibiting the ability of osteoclasts to break down osseous tissue. |
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| Alveolar bone destruction is mediated by activated osteoclasts. |
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| Among the cells they produced were osteoclasts, large white cells involved in the brittle bone disease osteoporosis, and eosinophils, which play a role in allergy and asthma. |
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| During bone metastasis, tumors invade the bone and take over the cells known as osteoclasts that normally break down old bone material as new material grows. |
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| Osteoclasts are multinucleated giant cells with unique morphological characteristics that allow them to resorb bone matrix. |
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