| When the synthetic peptide was used as the antigen, a monoclonal antibody was obtained. |
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| With the help of specially designed monoclonal antibodies, they collected devil's coach-horse beetles and analysed their guts. |
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| A monoclonal antibody to influenza nucleoprotein was purchased from QED Biosciences. |
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| By recognizing and attaching to these proteins, monoclonal antibodies can interfere with normal or abnormal cellular responses. |
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| Human leukocytes are identified by monoclonal antibodies that recognize leukocyte membrane molecules. |
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| One should note whether the antibody is polyclonal or monoclonal and also the species and isotype of the primary antibody. |
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| Most of these analytes are measured by immunoassays using monoclonal or polyclonal antibodies. |
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| The presence of parathyroid tissue was confirmed by positive immunoreactivity with a monoclonal antibody to parathormone. |
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| Traditionally, most methods have used monoclonal antibodies and immunohistochemistry to identify tumour marker proteins. |
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| Review of the flow cytometric immunophenotypic data failed to reveal a monoclonal B-cell or aberrant T-cell population. |
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| Flow cytometric immunophenotyping did not reveal an aberrant T cell or monoclonal B-cell population. |
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| These soluble molecules in the blood are usually glycoproteins detected by monoclonal antibodies. |
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| Pollen analysis enables the honey producer to identify whether the honey is monoclonal or polyclonal. |
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| Whether polyclonal proliferations progress to monoclonal lymphomas has not been proven. |
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| Additionally, a polyclonal intracerebral inflammatory response may precede the proliferation of monoclonal malignant lymphoid cells. |
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| Most scientists working with the new inhibitors and monoclonal antibody treatments acknowledge they will be used in combination with chemotherapy for years yet. |
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| The first reagent layer consists of polyclonal or monoclonal antibodies of reference quality. |
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| Other systemic therapies include monoclonal antibodies, protein specifically targeting memory T cells, fumaric acid esters, novel retinoids, and macrolactams. |
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| A monoclonal anti-idiotype antibody 3H1 produced by a hybridoma cell line ATCC No. HB12003 or progeny thereof. |
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| An injectable humanized monoclonal antibody is available for prevention of RSV infection in high-risk infants and children. |
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| These specific monoclonal antibodies recognize the extranuclear estrogen receptor of the MCF-7 human breast cancer cell line. |
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| The interior of the SPR is coated with monoclonal anti-staphylococcal enterotoxin antibodies. |
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| The active principles are either a soluble TNF receptor that binds to and inactivates TNF-alpha, or an anti-TNF-alpha monoclonal antibody. |
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| Action 68 Cofinancing of a European network of data banks for cel cultures producing monoclonal antibodies. |
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| Colouring of the 'electrophoretic' strips using monoclonal antibodies marked with peroxidase. |
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| A protective monoclonal antibody to a serotypic determinant of a flagellar antigen of a microorganism. |
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| What's more, they are hardier than monoclonal antibodies, the current standard antibody format for therapeutic purposes. |
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| Some monoclonal antibodies have been produced that appear to be effective as immunosuppressive agents in humans. |
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| So-called monoclonal antibodies can be produced in the laboratory and used therapeutically for the treatment of tumour cells. |
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| Finally, Dr. Edwards has developed a monoclonal antibody to the chicken oviduct progesterone receptor. |
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| The program also has expertise in the production of polyclonal and monoclonal antibodies and related techniques, such as radioimmunoassay. |
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| The facility will be used for the production of monoclonal antibodies and recombinant proteins based on mammalian cell culture technology. |
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| A monoclonal antibody-based ELISA can be used to study antigenic variation among strains of swine vesicular disease virus. |
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| It is used for the discovery and development of human monoclonal antibodies for both therapeutic and diagnostic applications. |
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| This new virus has been purified, further studied and monoclonal antibodies have been developed to detect it specifically. |
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| This technique is used on a large scale in the commercial production of monoclonal antibodies. |
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| Anti-human IL-2Ra monoclonal antibodies, including daclizumab, exhibit strict species specificity in their antigen-combining site. |
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| It has developed proprietary monoclonal antibodies to properdin that are potent in vitro and in vivo inhibitors of the complement alternative pathway. |
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| Herein, we report a case of monoclonal B-cell proliferation involving lymph nodes, bone marrow, and peripheral blood in a patient with Whipple disease. |
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| Evaluation of the bone marrow revealed a small monoclonal population of cytoplasmic kappa light chain-restricted plasma cells in an otherwise normocellular marrow. |
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| If the serum sample contains antibodies to swine vesicular disease virus, the binding of a selected peroxidase-conjugated monoclonal antibody to virus antigen will be inhibited. |
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| Patents have already been granted on immortalised cell-lines and hybridomas which are useful in research or as monoclonal antibody sources for research and diagnosis. |
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| A monoclonal antibody which binds to amino acid sequence IINMWQKVGKAMYAP in the CD4-binding region of the gp120 of HIV-1, and which shows neutralising activity against HIV-1 in a syncytium forming assay using CEM-SS cells. |
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| Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided. |
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| The technology includes monoclonal antibodies and related hybridomas and other related know-how. |
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| Vivalis' HUMALEX® platform is a potent technology for the discovery of fully human monoclonal antibodies produced by activated and immortalized B lymphocytes isolated from selected human donors. |
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| Immunophenotyping, the identification and quantification of cellular antigens with fluorochrome-labeled monoclonal antibodies is one of the most important applications of flow cytometers. |
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| For example, the NIH supported early research into monoclonal antibodies. |
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| Well 1A, contains a murine monoclonal antihuman B lymphocyte antibody. |
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| Moving forward we adopted a three pillar based development strategy for our products: our well known MVA technology platform, and two innovative approaches: oncolytic virus and monoclonal antibodies. |
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| Rituximab is a monoclonal antibody against CD20 antigen expressed on B-lymphocytes. |
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| Human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus induced monoclonal islet cell autoantibody. |
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| We produce peptides for antibody production, bioactivity testing, target affinity, binding kinetics, pharmaceutical and biotechnology applications, and polyclonal and monoclonal antibody production. |
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| Characterization of periplasmic protein BP26 epitopes of Brucella melitensis reacting with murine monoclonal and sheep antibodies. |
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| A monoclonal IgG antibody or IgG antibody fragment isotype which is engineered to contain a glycosylation site in the non-Fc constant heavy-chain region. |
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| It is possible that an autoantibody could give a false negative result in this assay due to steric hindrance of the human autoantibodies by the murine monoclonal antibodies used to capture the platelet glycoprotein. |
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| A mammalian monoclonal antibody which binds to human C1q in an immune complex but which does not detectably bind to human C1q in the C1 complex in serum. |
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| Most recently monoclonal antibody technology has been used to generate a number of monoclonal antibodies specific for antigenic determinants on or near the estrogen receptor site. |
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| All cryoprecipitates should be characterized for the presence of monoclonal components. |
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| Another long-term approach to pain control may be through the use of monoclonal antibodies which can be designed to bind with great selectivity to ion channels, membrane receptors or neurotransmitters. |
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| With the availability of hybridoma technology, different murine monoclonal anti-H have been reported from the West. |
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| This monoclonal antibody will cause cell death in only the T-lymphocyte population and is an additional indicator of the purity of B-lymphocytes in the cell preparation. |
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| The technology is a single-chain multivalent ligand trap that is able to offer the affinity and specificity of a monoclonal antibody, coupled with the size and ease of handling of a small molecule. |
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| Its properties as compared with monoclonal antibodies give it the potential to be a more powerful anti-angiogenic agent with a broader spectrum of activity. |
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| If the serum sample contains antibodies to swine vesicular disease virus, they are detected using an anti-pig IgG or an anti-pig IgM monoclonal antibody conjugated with peroxidase. |
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| Serological tests have been made more specific and convenient to perform since the discovery of a technique to produce large quantities of monoclonal antibodies, which bind to only one specific antigen. |
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| In the past, they have let countless lucrative innovations slip through their fingers, including monoclonal antibodies and erbium-doped optical fibres, both of which went on to become multi-billion dollar businesses. |
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| And when purified, such proteins can be used to treat diseases. Drug makers are especially keen to get their hands on large quantities of compounds known as monoclonal antibodies. |
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| The volume of distribution of the central compartment of tocilizumab was 3.5 L, which approximates the serum volume and is in the range of what has been previously described for IgGs and other monoclonal antibodies. |
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| I understand that you heard from IAVI regarding their success in generating neutralizing human monoclonal antibodies for the treatment and prevention of HIV infection. |
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| Vitellogenin uptake and vitellin localization in insect follicles examined using monoclonal antibodies and confocal scanning microscopy. |
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| Although monoclonal antibodies have reasonably long half-lives, market pressures for less frequent dosing schedules can reduce efficacy. |
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| No immunoreactivity was detected when a monoclonal antibody MiTF was used as the primary antibody in the negative control staining. |
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| Boehringer Ingelheim will then develop monoclonal antibodies and non-antibody products against selected targets primarily in the area of oncology and will be responsible for developing, manufacturing and marketing products. |
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| However, subsequent serum protein immunotyping failed to demonstrate a monoclonal protein. |
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| Confirmation of a monoclonal protein can be reliably done only by immunofixation or immunotyping. |
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| Palivizumab, an RSV-specific monoclonal antibody, can reduce the hospitalization rate and severity of illness for a small group of high-risk or premature infants during their first RSV season. |
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| Vivalis is today one of a very few companies able to propose a fully integrated offering from the discovery of fully human monoclonal antibodies to the production of clinical batches. |
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| The percentage of events reactive with each monoclonal antibody was determined, setting thresholds with isotypic controls. |
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| Serodiagnosis of human paragonimiasis by ELISA-inhibition test using monoclonal antibodies. |
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| Two different hollowfibre bioreactors were used for the production of a human monoclonal antibody for clinical use. |
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| Adalimumab is an IgG monoclonal antibody specific for TNF-alpha, thereby blocking its interaction with cell surface TNF receptors. |
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| Immunohistochemical diagnosis of systemic bovine zygomycosis by murine monoclonal antibodies. |
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| ThromboView uses a clot-binding monoclonal antibody attached to a radiolabel. |
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| The virus was then typed at the Institute Pasteur of Buenos Aires using monoclonal antibodies, where it was found to be antigenic variant 4 of serotype 1, i.e., the type of virus usually found in insectivorous bats. |
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| Development of a standardized subgrouping scheme for Legionella pneumophila serogroup 1 using monoclonal antibodies. |
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| A monoclonal antibody which is specifically reactive with a human ribonnucleotide reductase R2 subunit and which is capable of inhibiting ribonucleotide reductase activity. |
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| In addition, since populations of serologically related saprophytes can be increased, the use of specific monoclonal antibodies rather than polyclonal antibodies is recommended where the ELISA test is to be used. |
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| Valproic acid concentration in serum was measured by a specific monoclonal fluorescence polarization immunoassay. |
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| A bullous neutrophilic dermatosis in a patient with severe rheumatoid arthritis and monoclonal IgA gammopathy. |
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| Acromegaly associated with monoclonal gammopathy of undetermined significance. |
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| Scleromyxedema without monoclonal gammopathy is a rare and atypical variant of lichen myxedematosus. |
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| In humans with B-cell CLL, monoclonal hypergammaglobulinemia can occur. |
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| These 2 Waldenstrom macroglobulins were subsequently utilized by several investigators in a number of studies on monoclonal rheumatoid factors over the next 20 years. |
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| Remsima is the world's first biosimilar monoclonal antibody to be approved by the European Medicines Agency for the treatment of eight autoimmune diseases. |
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| This strategy is based on blocking the CGEN-15001T immune checkpoint protein, which we have demonstrated is expressed on cancer cells, using a therapeutic monoclonal antibody. |
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| One major bottleneck is developing the high-titer, stable mammalian cell lines needed to produce biopharmaceuticals such as monoclonal antibodies. |
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| When he had an evaluation at the hospital clinic, it was determined that he did have indeterminate hyperopacities on MRI of the brain and unspecified monoclonal gammopathy. |
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| The development of DNA vaccines and gene therapy vectors as well as genetic vaccination for monoclonal antibodies and antisera also profit from GENEART's technology. |
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| Continuous, perfusion bioprocessing is not really new, and has been used for decades for commercial biologic manufacture, including blockbuster monoclonal antibodies. |
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| Inflectra is a chimeric humanCaemurine monoclonal antibody that binds with high affinity to both soluble and transmembrane forms of TNF alpha but not to lymphotoxin alpha. |
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| In addition to reagent differences, limited subclass-specific epitopes may result in monoclonal IgGs having variable recognition by subclass-specific antisera. |
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