| Methemoglobinemia is detectable by measurement of blood levels of methemoglobin and is manifested clinically as cyanosis and hypoxia. |
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| In addition, the enzyme systems for reducing methemoglobin to oxyhemoglobin are incompletely developed in infants under six months of age. |
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| When nitrite enters the bloodstream, it reacts with the hemoglobin and forms a compound called methemoglobin. |
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| Determine methemoglobin concentration of blood every 3 to 6 hours for first 24 hours. |
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| The level of change is approximately equal to the amount of carboxyhemoglobin or methemoglobin present. |
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| Energy is also required to convert methemoglobin to oxyhemoglobin and to prevent the oxidation of other constituents of the red cell. |
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| In humans, methemoglobin formation is very rare at therapeutic doses and overdoses of acetaminophen. |
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| The major effect of nitrite is the oxidation of blood hemoglobin to methemoglobin, which is unable to transport oxygen to the tissues. |
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| From published information, nitric oxide is very rapidly inactivated by binding to hemoglobin to form methemoglobin. |
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| Sodium nitrite converts hemoglobin to methemoglobin which, together with sodium azide, gives azidemethemoglobin. |
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| An increase in methemoglobin concentration was observed, however, the increase was very slight and not statistically significant. |
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| In patients with normal reductase function, significant production of methemoglobin would require even larger doses of isosorbide-5-mononitrate. |
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| Nitrate ions liberated during metabolism of isosorbide-5-mononitrate can oxidize hemoglobin into methemoglobin. |
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| Red cells are lysed and potassium ferricyanide oxidizes hemoglobin to methemoglobin, which combines with potassium cyanide forming cyanmethemoglobin. |
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| The condition is extremely serious if it's not treated: death takes place when 70 per cent of the body's hemoglobin has been converted to methemoglobin. |
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| The red cells contain enzymes capable of maintaining the iron in its normal state, but under abnormal conditions large amounts of methemoglobin may appear in the blood. |
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| If quickly discovered, this disease can be successfully treated with an injection of methylene blue, which changes methemoglobin back to hemoglobin. |
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| However, the severity of clinical symptoms should be the primary consideration in the decision to initiate treatment, rather than the level of methemoglobin. |
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| If the iron itself becomes oxidized to the ferric state, hemoglobin is changed to methemoglobin, a brown pigment incapable of transporting oxygen. |
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| Based on an elimination half-life of 3 hours, the time to reach the steady state of percent methemoglobin concentration in anaesthetized dogs would be 12-15 hours. |
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| The fingertip device uses light that is shined through the patient's nail bed to measure carboxyhemoglobin and methemoglobin. |
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| Accumulation of methemoglobin occurs if this oxidation process overwhelms the protective reduction capacity of the cells. |
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