| They are purified cellfree hemoglobins, where the globin portion of the molecule has been modified chemically by conjugation, cross-linking or polymerizing. |
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| The thalassemias are another group of inherited disorders in which one or more of the polypeptide chains of globin are synthesized defectively. |
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| The globin fraction is a protein that may constitute more than 90 percent of the total molecular weight of hemoglobin. |
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| Each hemoglobin molecule is made up of four heme groups surrounding a globin group, forming a tetrahedral structure. |
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| Thalassemia is caused by genetically determined abnormalities in the synthesis of one or more of the polypeptide chains of globin. |
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| The different types of a-thalassemia are usually the consequence of deletional mutations involving a globin gene loci. |
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| The thalassemias are the result of genetic defects that limit the production of specific globin chains of the Hb molecule. |
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| In the large majority of cases of a-thalassemia, the a globin chains are structurally normal: they are merely reduced in quantity. |
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| There are rare non-deletional mutations affecting a globin production, such as Hb Quong Sze and Hb Constant Spring. |
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| Thalassemias are characterized by impaired quantitative synthesis of globin chains. |
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| If two mutated b globin genes are inherited, one from each parent, the patient may be clinically categorized as either b-thalassemia intermedia or b-thalassemia major. |
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| Abnormalities in the globin chains can lead to disease. |
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| A method of controlling beta dimer formation in a hemoglobin composition, comprising altering a metal binding site on a beta globin to prevent or reduce said beta dimer formation. |
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| Each donor underwent tests for blood pressure, sugar and hemo globin count before the donation. |
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| A variant in the globin genes can cause a host of systemic disorders, from sickle cell and other forms of anemia to thalassemia. |
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| In alpha thalassemia, at least one of the alpha globin genes has a mutation or abnormality. |
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| The equipment is held over the skin and uses near infrared light which is absorbed by the haemo globin in the blood. |
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| Structure Haemoglobin is a large molecule made in the bone marrow from two components, haem and globin. |
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