| The lesions of demyelination are histopathologically characteristic of the disease. |
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| It might, for example, be a factor in killing oligodendrocytes, and hence triggering demyelination in Multiple Sclerosis, an autoimmune disorder. |
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| Locked-in syndrome is caused either by a lesion in the brainstem or by extensive demyelination, denying the brain its peripheral connections. |
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| When Kyle had his first attack of demyelination, at age four, doctors at his local hospital were stumped. |
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| Pathologically, inflammation of the spinal cord meninges is coupled with varying degrees of underlying spinal necrosis, demyelination, and microglial influx. |
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| Subacute combined degeneration, which results from a vitamin B12 deficiency, causes demyelination of the corticospinal and the dorsal columns. |
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| We found that most MS lesions have already undergone demyelination by the time they are first visible on MR scans. |
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| We hypothesize that the protein composition of these lipid rafts changes during demyelination and the function of the myelin raft is disrupted. |
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| Tremors in mice with defective quaking proteins are due to demyelination, making this animal an important model for MS research. |
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| It appears to be due to demyelination within the central pathways for hearing within the brain. |
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| By further investigating changes to the proteome we can identify molecular targets that are affected during the demyelination process. |
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| Research confirms exposure to viruses, bacteria and other harmful microbes during childhood causes demyelination and inflammation. |
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| Exacerbations are usually associated with inflammation and demyelination in the CNS, resulting in new symptoms or the aggravation of old ones. |
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| Because of demyelination, the spinal cord is unable to forward the signals from the bladder all the way to the brain. |
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| If any of these pathways have been injured by demyelination, they will not send messages as quickly as they should. |
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| Multiple areas of demyelination must be confirmed by MRI scanning or imaging techniques generally used to diagnose multiple sclerosis. |
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| Similarly demyelination of the posterior columns of the spinal cord was observed in nearly half of the autopsied cases, while vacuolar myelopathy was rare. |
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| Multiple sclerosis typically begin in early adulthood and is characterized by multiple areas of demyelination and sclerosis of the brain, spinal cord, or both. |
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| Finally, given that demyelination in children occurs in the still developing brain and during the period of core academic study, we will also evaluate the impact of demyelination on learning. |
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| Antibodies to ganglioside structures of the microorganisms may cross-react to gangliosides of the myelin sheath or neurofibre and induce inflammation processes with subsequent demyelination. |
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| Severe neurologic toxicity can manifest as coma, status epilepticus, craniospinal demyelination, or ascending neuropathy similar in presentation to Guillain-Barré syndrome. |
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| Multiple sclerosis is a chronic, inflammatory medical condition that results in demyelination, axonal transection, and neurodegeneration. |
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| Could you tackle the controversy over rabies vaccines and demyelination in dogs? |
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| Diseases affecting the corpus callosum include Marchiafava-Bignami disease, which is characterized by progressive demyelination of the neurons of the corpus callosum. |
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| Paediatricians were asked whether the possibility of recurrent demyelination was entertained, as many health-care professionals may not consider MS as a possible diagnosis of an initial demyelinating event. |
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| We develop a demyelination of the optical nerve and the spinal cord in rats to generate a model of Neuromyelitis optica, a human demyelination disease which affects preferentially the optical nerve and the spinal cord. |
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| His research work has been on around mechanisms of remyelination and demyelination as well as oligodendrocyte and astrocyte behaviour in clinical Multiple Sclerosis and its models. |
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| In certain very rare diseases, known as leukodystrophies, large areas of demyelination occur in the white matter of the brain as a result of inherited metabolic disorders. |
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| Since many motor nerve fibres cross over and intertwine in the pons, the resulting swelling may lead to their compression and dysfunction, as well as to demyelination, a condition known as central pontine myelinolysis. |
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| The spinal cord is most often affected in such cases, but the optic nerves may show demyelination, loss of axons and gliosis. |
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| Multiple sclerosis is characterized by demyelination and neuronal damage as a result of infiltration of activated immune cells into the central nervous system. |
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| Other Neurologic Events: There have also been reports of events associated with demyelination and ascending peripheral neuropathies similar in appearance to GuillainBarré syndrome. |
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| All children and their families will be asked to tell us how demyelination has impacted their quality of life, so that we might better appreciate the consequences of this illness on child and youth health. |
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| Spinal demyelination in progressive multifocal leucoencephalopathy. |
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| Demyelination occurring during anti-tumor necrosis factor alpha therapy for inflammatory arthritides. |
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