| Aequorin, when bound to its cofactor coelenterazine, luminesces in response to calcium binding. |
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| Copper is usually utilized in organisms as a cofactor in enzymes or electron transfer proteins that catalyze redox reactions or oxygen chemistry. |
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| Modifications of proteins that depend upon vitamin C as a cofactor include proline and lysine hydroxylations. |
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| Thyroideal cells are exposed to endogenous H202 that acts as a cofactor for the iodination of thyroxin precursors. |
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| Thiamine pyrophosphate, the active form of vitamin B-1, is a key cofactor of the essential enzymes involved in carbon metabolism. |
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| The anaesthetics bind in a hydrophobic pocket which is the normal binding site for a necessary cofactor. |
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| Vitamin B 6 functions as a cofactor of many diverse enzymes in amino acid metabolism. |
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| Alcohol intake is a cofactor in the rate of progression of chronic HCV infection. |
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| Biopterin is a vital cofactor in tryptophan hydrolase's conversion of tryptophan to serotonin. |
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| To negate the effect of proximity to the microchip plant as a cofactor, the author compared clients and nonclients in the 3 zones of the exposure area. |
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| The trace element chromium is a cofactor for insulin and is important for glucose tolerance. |
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| A cofactor that is bound loosely to the apoenzyme and can be readily separated from it is called a coenzyme. |
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| In combination with a cofactor, it inactivates thrombin thus preventing the conversion of fibrinogen to fibrin. |
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| Although vitamin K is usually identified as a critical factor in blood coagulation, recent research has found that vitamin K is also a cofactor in bone metabolism. |
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| A trigger or cofactor role of ROCEPHIN-related biliary precipitation can not be ruled out. |
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| Continued research into SV40 will be important as SV40 may yet prove to be a cofactor in the development of certain types of cancers. |
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| Along with changes in eNOS, the enzyme responsible for the production of the eNOS cofactor, tetrahydrobiopterin was also increased. |
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| Copper is an essential cofactor for approximately a dozen copper-binding proteins for the proper regulation of copper homeostasis in humans. |
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| Anorectal infections are a potent cofactor for HIV transmission. |
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| Like fireflies, they too rely on a cofactor, in this case calcium ions rather than magnesium. The light-generating reactions used by fireflies and jellyfish occur in many other organisms. |
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| A cofactor may be either tightly or loosely bound to the enzyme. |
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| Other experiments will utilize aldo-keto reductases that utilize NADPH as a cofactor. |
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| A cofactor may be a metal such as iron, copper, or magnesium a moderately sized organic molecule called a prosthetic group, or a special type of substrate molecule known as a coenzyme. |
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| If tightly connected, the cofactor is referred to as a prosthetic group. |
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| Amine oxidases present a class of enzymes, which are divided into two main groups based on the chemical nature of the attached cofactor. |
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| It is the direct precursor to serotonin synthesis via the enzyme aromatic amino acid decarboxylase, which requires vitamin B6 as a cofactor. |
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| Similar to copper, iron is both essential as protein cofactor but also dangerous as ferreous iron catalyzes the formation of reactive oxygen species. |
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| However, rare cases of PKU that result from impaired metabolism of biopterin, an essential cofactor in the phenylalanine hydroxylase reaction, may not consistently respond to therapy. |
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| Use of a modified human heparin cofactor II wherein the leucine residue at position 444 is replaced by arginine, for the manufacture of a medicament for use in human antithrombotic methods. |
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| Results of assays for von Willebrand's disease were normal, including ristocetin cofactor, factor VIII assay, and von Willebrand's antigen. |
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| In the synthesis of collagen, ascorbic acid is required as a cofactor for prolyl hydroxylase and lysyl hydroxylase. |
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| The vitamin is a cofactor for the synthesis of collagen, the predominant protein in skin. |
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| Pyrroloquinoline quinone functions as a cofactor for prokaryotic oxidoreductases, such as methanol dehydrogenase and glucose dehydrogenase. |
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| It could also help chemists design artificial cofactor molecules and enzymes to catalyse reactions which are currently difficult or impossible. |
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| It is an important cofactor to several enzymes, including acetyl CoA carboxylase and other carboxylases. |
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| Since NADPH is a cofactor for the production of superoxide dismutase, other conditions which affect the formation of NADPH can also lead to impaired neutrophil function. |
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| Trypanothione reductases catalyse the transfer of electrons from the cofactor of NAPDH to trypanothione substrate by the action of FAD and cysteine disulfides. |
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| In the case of PNPO deficiency, plasma AADC activity can be increased, probably owing to upregulation of apoenzyme synthesis in the absence of the PLP cofactor. |
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| Whether Chlamydia was the primary pathogen responsible for the die-off or served as a cofactor with the chytrid fungus or other parasites was difficult to determine. |
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| On the other hand, the relative risk model means that ionizing radiation is a cofactor of cancers, which was not necessarily the case for an absolute risk model. |
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| It also serves as an important cofactor in the synthesis of epinephrine. |
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| Assembly and maturation mechanisms of respiratory complexes remain enigmatic because of their membrane location, multisubunit composition and cofactor insertion. |
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| Rivaroxaban has been reported to bind both to free factor Xa and to factor Xa in prothrombinase complex without the need of antithrombin as a cofactor. |
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| The biotechnology company's cancer-drug candidate CoFactor failed to meet its goal in a midstage study. |
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| The Company's lead compound, CoFactor, is a biomodulator of 5-fluorouracil, a widely used cancer chemotherapy. |
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