How to use cell cycle in a sentence

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Sentence Examples Tyrosine kinases associated with cyclins have also been shown to be affected by vitamin K, which can lead to cell cycle arrest and cell death. Cells may exit the cell cycle at G 1 and enter a nonproliferative phase called G 0 or quiescence. Our cutting-edge tools can help simplify your cell division, mitosis and cell cycle research. It is through changes in the production of cyclins during the cell cycle that the activity of the genes controlling it are themselves regulated. To address this, we used a time-lapse imaging technique to directly measure cell cycle parameters in living embryos. During balanced growth, cells undergoing binary fission must double the number of every kind of RNA and protein molecule every cell cycle. The single SPB that is present at the beginning of the cell cycle must duplicate to generate the two poles of the bipolar spindle. The events in this stage of the cell cycle leading to cell division are prophase, metaphase, anaphase and telophase. During meiosis cells exit the vegetative cell cycle and enter a linear divisional and differentiation pathway. A critical step in the cell cycle is the proper attachment of chromosomes to the mitotic spindle during metaphase. Path diagram for a genetic network of nine genes reconstructed from yeast cell cycle data. It is a cytostatic drug that stops cell division very early in the cell cycle without causing cell death. Cells with white cytoplasm represent cells that are actively undergoing nuclear division at the designated cell cycle stage. To examine Tetrahymena RAD51 expression through the cell cycle, a synchronous population was obtained by centrifugal elutriation. Every second millions of cells divide in our body and the process of division is called the cell cycle. We found a small subpopulation of cells that could, with proper stimulation, re-enter the cell cycle. In general, cyclins are proteins that regulate the cell cycle by combining with cyclin dependent kinases to form an enzymatic complex. The de novo assembly of silent chromatin requires passage through the S phase of the cell cycle. Proteasome degradation of cyclins involved in cell cycle regulation has been well documented. The ultimate conclusion of one cell cycle is cytokinesis resulting in two identical daughter cells. Show More Sentences It has been reported recently that regulated nuclear transport of cyclins and other proteins is required for cell cycle progression. In the cell cycle, these two cytoskeletal structures drive chromosomal separation and cell division. The actin cytoskeleton has long been known to be a key regulator of cell proliferation linking biochemical sensing of the environment with cell cycle progression. The first is related to the 'traditional' activity of this unit, i.e. studies on the cell cycle and very early embryogenesis. Cell cycle analysis showed cytocompatibility without any cell cycle arrests. We have recently identified novel molecular mechanisms regulating the Polo kinase during the cell cycle in the fly. Unicellular yeast-like fungi are different from filamentous fungi in that polarized growth is limited to that phase of the cell cycle in which the bud is formed. The human heart's ability to regenerate is lost during the perinatal transition, when cardiomyocytes exit the cell cycle shortly after birth. In budding yeast, many genes are induced early in the cell cycle. What if it was our own genetic code that was responsible for inviting HIV into the life of a cell cycle? Starting at the macroscopic chromosome level we see that its structure can strongly vary throughout the cell cycle on timescales of hours or days. Progression of the cell cycle depends on the additional activity of cyclin-dependent kinases. It is a highly sophisticated assembly whose shape can vary depending on metabolic needs, the cell cycle or the environment. Our current efforts are targeted at understanding how changes in chromatin structure are regulated by the cell cycle machinery during mitosis. The typical cell cycle for a nuclear plant can fluctuate from 5 to 15 years. The cells in different cell cycle phases were collected, and cell cycle distribution in each of the fractions from centrifugal elutriation was confirmed by flow cytometry. The head of his laboratory is Tim Hunt, who will go on to win the 2002 Nobel Prize for his work on cell cycle regulation. The latter was due to the interruption of the cell cycle related to proteasome inhibition. Recent analysis of the Drosophila genome sequence supports previous suggestions of strong parallels between many fly and vertebrate cell cycle regulators. Although ribosome biogenesis has been extensively studied, the nature of the coordination between this process and the cell cycle remains poorly understood. Show More Sentences Failure of Eg5 function leads to cell cycle arrest in mitosis with monoastral microtubule arrays. After the fungus breaks through the plant cell wall, it should plunder nutrient from its host for living, and accelerates the cell cycle and starts the cellular responses to nutrimental levels. Generalities regarding cell cycle, cell cycle horologe control. Contrary to gamma radiation, Jurkat cells do not completely halt the cell cycle 24 h upon haemanthamine and haemanthidine exposure. The dynamic exchange of these progenitor-specific subunits for the homologous BAF45b, BAF45c and BAF53b subunits during neural development is essential for cell cycle withdrawal and the acquisition of neuronal properties. Disappearance and reappearance of the nuclear envelope during cell cycle is controlled by intermediate filament phosphoprotein called lamin. Hunt's key breakthrough about the cell cycle, the discovery cyclins, centred on his experiments with sea urchins and clams in the Marine Biology Laboratory, Woods Hole. Cyclins, cyclin-dependent kinases, and tumor suppressor gene products interact and regulate the normal cell cycle. Cytokinin controls the cell cycle at mitosis by stimulating the tyrosine dephosphorylation and activation of p34cdc2-like HI histone kinase. The cellular events which control these different forms of schizogony are likely to be very different from cell cycle control during binary fission and have not yet been fully elucidated. Chk1, in turn, works to temporarily halt the cell cycle by phosphorylating another protein. Boehringer Ingelheim's research efforts are focused on three main areas: angiokinase inhibition, signal transduction inhibition and cell cycle kinase inhibition, under which BI 6727 falls. A cell-free system for initiating DNA replication under cell cycle control, including S phase cytosol or a fraction thereof in which are co-incubated G1 phase nuclei, and S phase nuclei or a fraction thereof. It seems likely that the epidermis does indeed contain noncycling cells, which can become activated, and that the cell cycle in psoriatic epidermis is speeded up only about twofold, not twelvefold, as once proposed. We address these questions using one of the very best model organism available for the analysis of eukaryotic cell cycle regulation, the budding yeast Saccharomyces cerevisiae. His interest in studying the cell cycle in the context of a metazoan model took him to the lab of David Glover in the Department of Genetics at the University of Cambridge as an EMBO fellow and subsequently as a HFSP fellow. Specifically, our work aims to understand how cells integrate various signals coming from extra-cellular factors and intrinsic tumor suppressor gene products into the regulation of growth, cell cycle progression and survival. As a whole, our research program integrates fundamental aspects of cell biology such as how cell signaling by proteases and protein kinases regulates cell cycle progression and chromatin structure in dividing cells. In some current experimental procedures, the donor cell may be treated with chemicals to modify its composition, for example cell cycle inhibitors or chromatin modifiers. He showed that these forces are coordinated during the cell cycle and that a transition between different types of forces coincides with the beginning of the shift of the mitotic spindle. Show More Sentences The family of cyclin-dependent kinases are regulators of the cell cycle. We measured cell cycle distribution and apoptosis using propidium iodide staining and a flow cytometer as described previously by Mandil et al. The initiation of DNA replication is linked both to cell cycle progression and chromatin organization. We focused on the PAF1 complex which has been previously implicated in gene transcription, cell cycle control and mRNA surveillance. The cell cycle deregulation leads to neurogeneration. Right: Statistics for cell cycle distribution. Disorganized tubulin polymerization prevents cell cycle progression. When one is in the time scale of several tens of minutes, it is interesting to note that there is possible overlap with the length of the cell cycle of certain bacteria. It is particularly important that cell culture conditions ensure a cell cycle time within the normal historical range of the cells or cell line used. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Human diploid fibroblasts cultured under normal conditions have been reported to develop an irreversible cell cycle arrest, referred to as replicative senescence. A study with pure prodelphinidin B3 and C2 showed that they inhibit the growth of prostate cancer cells through cell cycle arrest and caspase-3 activation. And the proliferation, clonability, migration, invasion and cell cycle of ovarian cancer cells are significantly correlated with the expression of clusterin. Docetaxel, a microtubule stabilizing agent, has been reported to interfere with spindle microtubule dynamics causing mitotic cell cycle arrest and apoptosis. The growth-related, translationally controlled protein P23 has properties of a tubulin binding protein and associates transiently with microtubules during the cell cycle. Phenotypic variation and gene regulation are covered next, with discussion of multicellular behavior, social signals, differentiation, the cell cycle, and developmental genes. Mitosis is a part of the cell cycle process by which chromosomes in a cell nucleus are separated into two identical sets of chromosomes, each in its own nucleus. Find more words! 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