| The effectors that modulate the activity of these allosteric enzymes are of two types. |
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| Physiological biochemistry has emphasized the role of key regulatory enzymes that display allosteric control and nonequilibrium reaction states. |
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| All of the interacting proteins and protein enzymes involved in allosteric regulation are controlled by gene expression. |
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| Could similar phenomena occur at other enzymes, particularly allosteric enzymes where structurally similar dihydrofolate plays a regulatory role? |
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| Addex Pharmaceuticals discovers and develops allosteric modulators for human health. |
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| These mechanisms include allosteric regulation, regulation by reversible covalent modification and regulation by control proteins such as calmodulin. |
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| Although numerous allosteric enzymes were studied, much less information is available concerning the coordinated regulation of activities in multienzymatic complexes. |
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| Frequently, an end-product of a metabolic pathway serves as an allosteric inhibitor on an earlier enzyme of the pathway. |
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| Some allosteric enzymes exhibit mixed homotropic and heterotropic interactions. |
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| Changeux and Edelstein, who were significant contributors to research on the nicotinic receptors for acetylcholine and allosteric proteins. |
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| Addex's competence in drug development and its expertise in allosteric modulation were recognised in a collaboration established in 2004 with Ortho-McNeil Pharmaceutical, Inc. |
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| Domain Therapeutics discovers allosteric modulators for GPCRs such as lipidic and peptidic receptors, which are difficult to address. |
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| In this case a rise in the level of the allosteric effector would affect the flux of nutrients along that pathway in a manner analogous to the feedback phenomena of homeostatic processes. |
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| An activator molecule can be bound to an allosteric site and induce a reaction at the active site by changing its shape to fit a substrate that could not induce the change by itself. |
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| The compounds are referred to as allosteric modulators and potentially offer advantages over conventional competitive agonist and antagonist compounds. |
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| This partnership represents a strong validation of our discovery platform and highlights the value of Addex' proprietary expertise in the allosteric modulation of GProtein Coupled Receptors. |
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| As ADX10059 is a selective mGluR5 negative allosteric modulator, it may have the possibility to reduce inappropriate esophageal sphincter relaxations and prevent reflux in man. |
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| Our lead allosteric modulator product, ADX10059, has achieved clinical proof of concept and is in Phase IIb testing for the treatment of GERD and, separately, migraine headache. |
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| In heterotropic allosteric regulation, the bacterial enzymes are activated by ADP and inhibited by phosphoenolpyruvate binding at the allosteric site. |
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| It interacts with an allosteric site just outside the antigenic peptide-binding site on MHC class II molecules in a manner to loosen antigenic peptide binding in that site. |
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