| Indeed, evidence supports that active TrPs release algogenic substances that are susceptible to promote the sensitization of muscle nociceptive nerve terminals, which may be responsible for muscle pain. |
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| Thus, the mechanical compression of bone tissues and the algogenic substances released by the bone environment and tumor at day 8 are not sufficient to exacerbate nociceptors and stimulate abnormal neuronal firing. |
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| The vascularising action produces an increase in blood flow, consequently affecting positively the elimination of algogenic substances and a re-establishment of normal physiological conditions. |
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| Release of prostaglandins E and F in an algogenic reaction and its inhibition. |
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| For instance, as the strongest vasodilator substance, CGRP also is endogenous algogenic substance, which is widely distributed in trigeminal nerve. |
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