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What does up and running mean?

Looking for the meaning or definition of the word up and running? Here's what it means.

Adjective
  1. (idiomatic) operational, in operation
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Examples
Once up and running, the Government funds them directly and the sponsor controls the academy independently of the local authority.
Her current assignment is getting the new flagship store up and running well in time for Christmas.
Using two iterations, I had nine polyphonic instruments up and running, with polyphony occasionally spilling over 100 notes simultaneously.
She could be dead asleep, but if she hears a pin drop in the hallway, she's up and running to the door, barking like a madman.
The Treasury has promised that the first Child Trust Fund accounts will be up and running by April 2005 at the latest.
This plant will produce up to 70 million litres of bioethanol each year when it is up and running.

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