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What is a ruination?

What is a ruination? Here are some definitions.

Noun
  1. The state of being ruined, a state of devastation or destruction.
  2. The act of ruining or wrecking.
  3. The cause of being ruined, destroyed or lost.
  4. A loss of reputation.
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Examples
There were no thanks, no acknowledgments, just a pointed few words on how the collapse of marriage could bring ruination to society.
But he had his own path to ruination he was set upon, and my being around did nothing to deter him.
And it is David's well-meaning employment of Sheila as a secretary that leads to his ruination.
Compared to the natural process of ruination, human destruction seems much more ferocious.
In experiencing uncanniness, the ruination and questionability of life are encountered.
The principal cause of ruination is wanton excess through the sin of hubris.

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