| They had a profound effect on the young Pascal and he became deeply religious. |
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| Unfortunately, we have little empiric evidence that demonstrates the profound effect that it can have on altering physician practice patterns. |
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| It is evident that e-mail viruses have had the most profound effect on data backup procedures. |
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| Although there is no evidence that the path has led residents to drive less, it did have a profound effect on their lives. |
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| These experiences had a profound effect and undoubtedly stirred her powerful maternal feelings. |
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| The circulation of engravings after German Nazarene artists also had a profound effect. |
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| Last week's unprecedented events could have a far more profound effect on economic psychology than other catastrophes. |
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| The experience had a very profound effect on me, both emotionally and spiritually. |
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| The competitive dynamics among siblings can have a profound effect on their growth and survival and, thereby, also on parental fitness. |
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| How many people here have been told that they have have had a profound effect and influence on their friends' lives? |
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| However, this software already has had a profound effect on the personal computing industry. |
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| The abolition of free sight tests in 1988 had a profound effect on opticians and led to consolidation in the industry. |
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| It had some sort of profound effect upon me as later that afternoon I had a wash, including my hair, and changed my underwear. |
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| This re-organization is having a profound effect on social relations and domestic arrangements in the main family entertainment room. |
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| This schism had a profound effect on the events that followed in the denomination. |
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| The increased food prices will obviously have a profound effect on a population that is already very vulnerable. |
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| Witnessing the devastation and tragic scenes of human suffering left an indelible impression on Burchett and had a profound effect on the rest of his life. |
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| This could have a profound effect on human dietary preferences and associated health consequences. |
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| Our actions and decisions, particularly those regarding our use of energy resources, have a profound effect today and on future generations. |
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| At all times of the year, in fact, the nature of underground formations has a profound effect on the volume of surface runoff. |
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| This had a profound effect on the profitability of a large number of farms. |
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| Jay Willman says crime has a profound effect on youth in the school's neighbourhood, the poorest urban riding in all of Canada. |
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| Receiving that ball and attending those games had a profound effect on my life. |
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| Japan's earthquake in March has had a profound effect on global industrial production, the most important determinant of commodity prices. |
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| Some of these strains can have a profound effect on the nervous system, and contribute to postnatal depression. |
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| The diverse activities typical of these urban agglomerations have a profound effect on air, water and soil quality. |
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| The resulting alteration of the crop geometry can have a profound effect on radar backscatter. |
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| American penologist, social worker, and writer who had a profound effect on American penal reform in the late 19th and early 20th centuries. |
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| The fact is that the absence of a parent has a very profound effect. |
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| Having this institution of higher learning in the Nass Valley has had a profound effect on completion rates, community spirit, and pride. |
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| Design Note: Weather did not have a profound effect on the air war in this theater of operations. |
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| Mental stress and depression can have a profound effect on cardiovascular disease and have implications in recovery. |
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| The environmental justice movement has had a profound effect on environmentalism and on environmental health. |
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| Exercise, too, can give you a real high and has been shown to have a profound effect on people who are depressed, possibly by releasing endorphins in the brain. |
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| Indeed it claimed so many lives and had such a profound effect on the Armenian community as well as on other communities in the region. |
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| Budgetary allocations can have a profound effect on the extent to which effective collective bargaining is feasible. |
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| This flexibility and adaptability has had a profound effect on first-generation American-born Thais, who tend to be quite assimilated or Americanized. |
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| Experiences during pregnancy, birth and infancy have a profound effect on the health and well-being of infants and young children. |
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| It is hard to explain the profound effect this film had on Australian consciousness about climate change. |
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| Studies of contemporary ice sheets show that the pattern of ice flux within ice streams has a profound effect on mass balance, flow configuration and ice divide positions. |
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| Climate change is expected to have a profound effect on New Brunswick in the future. |
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| When child workers speak about or act out events in their own lives it often has a profound effect on their audience, whoever they are. |
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| Whether a child is raised within or without a family, both circumstances will have a profound effect upon that child's social development. |
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| However, it is not well understood how one small change in a protein's structure can have such a profound effect on its functionality. |
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| This aspect of internet use is having a profound effect on who the users are. |
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| It changed him significantly, altered his ideas, and I believe had a profound effect on his best friend Martin. |
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| At the end of the day it was just four scallies trying to make an album and it's had a profound effect on a lot of people, and that's what you do it for, innit? |
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| Nevertheless, the justices continue to have a profound effect on some of the most hot-button issues in America. |
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| The unexpected visit of Niresh, his Canadian cousin, has a profound effect on Amrith's life, and brings about a sexual awakening of his own true nature. |
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| Roman culture had a profound effect on the Celtic tribes which came under the empire's control. |
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| We understand that work-life balance, feeling fairly treated at work and faring well at home have a profound effect on how well our people serve our customers. |
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| This changeability of the weather, not only season by season but day by day and even hour by hour, has had a profound effect on English art and literature. |
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| This episode is a perfect illustration of the cavalier way in which this Parliament too often goes about its business, and that is no laughing matter given the profound effect the EU has on people's daily lives. |
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| Whilst pretending not to realise what a profound effect such policies will have on the economic and social situation of the Member States, they continue to propound more of the same, which we roundly reject. |
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| Currently, the crisis is having a profound effect on social aspects and employment, triggering an ethical crisis of values, with a latent permanency already in place. |
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| While a discussion of these incidents may seem like a digression, it is important to describe their profound effect on air service to small airports. |
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| Bright-eyed Milanija Lackner is too young to understand that a grassroots first birthday campaign in her name could have a profound effect on the lives of her aunt and mother, and possibly even her own future. |
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| The daily barrage of nuclear intimidation from North Korea is exerting a profound effect on the opinions of people who were once committed to pacifism. |
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| Since the modern PDO era changes have had a profound effect on the climate of western North America one can but wonder at the change that would occur if an 1840 AD sized change occurred again with its apparent suddenness. |
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| The policies we adopt for the development of our water will have a profound effect in the years to come upon our domestic, agricultural, and industrial economy. |
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| Zia may have lacked popular support, but his policies of militarization and Islamization had a profound effect on State institutions and their responses to democracy and human rights. |
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| Once certain truths and facts are made known and certain taboos are broken, this does have a profound effect in terms of emboldening people to ask for change. |
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| This would also have a profound effect on coastal ecosystems, including loss in the productivity of estuaries, changes in barrier islands, wetland loss and increased vulnerability to coastal erosion and flooding. |
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| Other ocean phenomena, such as El Nino, have also been demonstrated to have a profound effect on weather patterns impacting the livelihood of coastal communities and the health of many fish stocks. |
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| The concise and powerful words of Yvonne Margarula, their elder and spokeswoman, were translated into English and French and had a profound effect on the Committee's deliberations. |
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| The question and the underlying assumptions are often ill-informed but the move to digital technology by media organizations is having a profound effect on archiving practice, access demand and strategic planning. |
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| The discovery of Dionysius had a profound effect on Eriugena's thinking. |
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| The reclining figure was to have a profound effect upon Moore's work, becoming the primary motif of his sculpture. |
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| These events, together with the Conscription Crisis of 1918, had a profound effect on changing public opinion in Ireland. |
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| Greene had a history of depression, which had a profound effect on his writing and personal life. |
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| His father's death in 1829 had a profound effect on him, and thereafter he was subject to bouts of depression. |
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| Invaders, colonisers, missionaries, merchants and traders brought cultural changes that had a profound effect on building styles and techniques. |
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| The presence of so much ice upon the continents had a profound effect upon almost every aspect of Earth's hydrologic system. |
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| What was previously a kelp forest becomes an urchin barren that may last for years and this can have a profound effect on the food chain. |
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| Which of these two process involved in the formation of a seamount has a profound effect on its eruptive materials. |
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| Democracy and republicanism would grow to have a profound effect on world events and on quality of life. |
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| I believe we are gradually making a difference as to what is regarded as acceptable and normal and that that will have a profound effect over time. |
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| What was that about motherhood's profound effect? |
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| They replaced social relations based on obligations and privileges with those based on contractual equality, and thus had a profound effect on the family. |
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| I keep copies of letters in my desk that have had a profound effect on me. |
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| Many of us recognize that sports and recreation can have a profound effect on disabled persons' recovery and reintegration into their communities but we have a hard time convincing donors of this fact. |
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| As a result, it could have had a profound effect upon the future evolution of the country while also serving as a mirror reflecting who we are for the world, along with our own descendants, to see. |
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| And what happens in the region will have a profound effect on the world. |
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| It was called the Chronically Sick and Disabled Persons Act, perhaps not the snappiest of titles, but went on to have a profound effect on many people. |
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| This revival in particular had a profound effect on Welsh society. |
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| The Scottish Renaissance also had a profound effect on the Scottish independence movement, and the roots of the Scottish National Party may be said to be firmly in it. |
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| Killer whales are apex predators throughout their global distribution, and can have a profound effect on the behavior and population of prey species. |
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| However, the Renaissance had a profound effect on contemporary theology, particularly in the way people perceived the relationship between man and God. |
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| Once it had been accepted as genuine, The Description of Britain exerted a profound effect upon subsequent theories, suppositions, and publications of history. |
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| The book had a profound effect on his impressionable young mind. |
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