Passage through mitosis is driven by precisely-timed changes in transcriptional regulation and protein degradation. |
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The activation energy is an important factor for predicting changes to material properties. |
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No one is sure how these changes will impact our relations with other countries. |
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There were dramatic changes in the role of women and men, in the value placed on women's work within the traditional economy and within the internal dynamics of their society of origin. |
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This represents a structure for the end of pressure vessels, most applicably plate heat exchangers, for reducing the effects of movement changes and vibrations. |
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We need to look at these proposed changes with a critical eye before we accept them. |
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The book describes the changes that have occurred in the landscape over many millennia. |
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There are several causes of cultural change, including changes in the societal conditions, cultural diffusion, innovation, and the imposition of cultural change. |
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The structure of the corona changes when the micelles interact. In particular, the extent to which the coronal layers contract or interdigitate upon an increase in. |
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The pamphlet provides a lot of information on recent changes to the tax laws. |
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Some employees are muttering about the changes in the pension plan. |
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The new president plans to make changes to the company's organization. |
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The liquid expands and contracts with changes in temperature. |
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Inversion of the two words changes the meaning of the sentence. |
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During this period, substantial governmental changes to land tenure occurred. |
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These changes have greatly depreciated the value of the house. |
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Children go through many changes during the period of adolescence. |
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There have been a lot of changes during the past two decades. |
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Despite the changes, he did not waver from his plan to retire. |
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The new president has made some radical changes to the company. |
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It's difficult to infer how these changes will affect ordinary citizens. |
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The price sometimes changes dramatically from one month to the next. |
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The changes to the manuscript are being keyed by the typist. |
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It's difficult to imagine that these changes will really be effective. |
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Waters claimed that, without Antonioni's constant changes to the music, they would have completed the work in less than a week. |
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There were also changes in the music industry, as record companies disappeared and merged into large media conglomerates. |
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Frequent tempo and time signature changes and syncopation are also typical. |
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In the 2000s, changes in the music industry and in music technology enabled a new wave of indie rock bands to achieve mainstream success. |
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Multiple changes were made to the bill in the days leading up to the festival. |
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The negative reaction to Monsieur Verdoux was largely the result of changes in Chaplin's public image. |
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The quick changes of mood and manner absorbed me, and I have never forgotten them. |
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During the second half of the decade, major changes were made to the conductorship of the orchestra. |
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Epilepsy is not a mental illness. It is caused by electrical changes in the brain. |
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The fielding captain often tactically changes their position between balls. |
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At this point, another bowler is deployed at the other end, and the fielding side changes ends while the batsmen do not. |
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Regular changes to the pitch mean that it never matches the quality of its surroundings, or of the pitch of the old Wembley in its later years. |
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However, the proposed changes were criticised by some for not going far enough, particularly to improve minority representation. |
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They meet at least once a year to debate and decide any changes to the text as it exists at that time. |
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Each club is a shareholder, with one vote each on issues such as rule changes and contracts. |
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In August 2016, UEFA announced changes in the access list of the tournament, driven to avoid the creation of European Super League. |
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A poor season on the field in 1889 was reflected by reduced income and changes were made with several good new players being introduced. |
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The evolution of the Olympic Movement during the 20th and 21st centuries has resulted in several changes to the Olympic Games. |
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White was credited with revolutionising Leicester's player in response to rule changes which opened up the game. |
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Each member receives a badge and membership card, the design of which changes at the start of each season. |
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Since then a large number of changes have been made to the exemption criteria and to the qualifying system for the remaining players. |
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For the 2016 Ryder Cup there were a number of changes from 2014 in the American system. |
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It is a very significant fact that similar changes occur in endometrium which is the seat of certain types of metropathia. |
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For 1958 drastic rule changes were introduced into Formula One, Fangio had retired and Maserati had withdrawn due to financial difficulties. |
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Since he had left it in 1993, the team had undergone some significant changes. |
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While it was never raced in Formula One due to technical changes, WHP has since seen its technology adapted for a range of applications. |
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Other changes for the team saw Jason Plato replacing Hoy, taking third in the championship. |
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In cases of technical modifications, the MSMA can unilaterally enact or veto changes by unanimous vote among its members. |
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Carmelo Ezpeleta, the CEO of Dorna Sports, indicated that the projected changes were received by the teams favorably. |
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After these changes, the theatre was leased by Archie Pitt, then husband of Gracie Fields, who appeared in the theatre. |
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For general sailing, during such course changes, there is work that needs to be done. |
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The town council of Faversham changes only the hindquarters of the three lions to silver. |
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Many species of oaks are under threat of extinction in the wild, largely due to land use changes, livestock grazing and unsustainable harvesting. |
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Religious observance of St George's day changes when it is too close to Easter. |
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Yet it is unclear whether these political changes will be enough to reverse the decline of minority Romance languages. |
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Stress in the Romance Languages mostly remains on the same syllable as in Latin, but various sound changes have made it no longer so predictable. |
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In these languages, however, further sound changes have resulted in various irregularities. |
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Significant sound changes affected the consonants of the Romance languages. |
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These sound changes may be due in part to the influence of Continental Celtic languages. |
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The position between a continent and an ocean means that weather often changes. |
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However, on 25 October 2007, changes were made such that the entire country is one electoral district, giving each vote equal weight. |
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The table below details changes in members' allegiances and parties' seat possessions. |
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The changes to the Assembly's powers were commenced on 4 May 2007, after the election. |
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After approval, only minor editorial changes are introduced into the final text. |
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Examples of this can include disciplinary action for rule infractions and deciding on rule changes in the sport that they govern. |
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He imposed rational legal systems and demonstrated how dramatic changes were possible. |
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Many cooperate with similar bodies from other countries to agree rule changes for their sport. |
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Many island countries rely heavily on imports and are greatly affected by changes in the global economy. |
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She has seen major constitutional changes, such as devolution in the United Kingdom, Canadian patriation, and the decolonisation of Africa. |
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The history of the concept of GDP should be distinguished from the history of changes in ways of estimating it. |
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In early 2014, David Cameron outlined the changes he aimed to bring about in the EU and in the UK's relationship with it. |
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The Viking Age brought great changes in Britain and Ireland, no less in Scotland than elsewhere. |
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The changes that David was most noted for at the time, however, were his religious changes. |
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The Protestant position, however, would come to incorporate doctrinal changes such as sola scriptura and sola fide. |
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The Highland Clearances and the end of the township system followed changes in land ownership and tenancy and the replacement of cattle by sheep. |
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These dramatic changes were accompanied by social unrest and the rise of populist, socialist, and anarchist movements. |
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The country's high rate of incarceration is largely due to changes in sentencing guidelines and drug policies. |
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Enclosure was not simply the fencing of existing holdings, but led to fundamental changes in agricultural practice. |
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Another key aspect of French success was the changes wrought in the officer classes. |
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Epidemic diseases and famine caused major disruption and demographic changes. |
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The appointment in 1848 of Lord Dalhousie as Governor General of the East India Company set the stage for changes essential to a modern state. |
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Epochal volcanism and climatic changes 20 million years ago forced a mass extinction. |
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The Industrial Revolution began in Britain due to the social, economic and political changes in the country during the previous centuries. |
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The Treaty changes the way in which MEP seats are apportioned among member states. |
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The effect of the Big Bang led to significant changes to the structure of the financial markets in London. |
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Many of the Neolithic settlements were abandoned around 2500 BC, possibly due to changes in the climate. |
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It is formed as a mountain stream drops over a cliff and changes character to a lowland river, the Afon Rhaeadr. |
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The changes took effect in 1996 with shadow councillors elected in 1995 to oversee the smooth transition of control. |
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The end of the war, however, was to cause profound change in Bermuda, though some of those changes would take decades to crystallise. |
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I believe that most people in the Turks and Caicos will welcome these changes. |
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The Jamaican Labour Party, which opposed the changes, won the election and has promised to hold a referendum on the issue. |
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Several significant changes were made to the Court during the 19th century. |
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The CTA has meant that Ireland has been required to follow changes in British immigration policy. |
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Today, the Royal Marines are an elite fighting force within the British Armed forces, having undergone many substantial changes over time. |
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Critics claim that the changes could fail to address some labour rights issues. |
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Representatives at the Congress agreed to numerous other territorial changes. |
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In 1953, changes in political leadership on both sides shifted the dynamic of the Cold War. |
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With the changes of the international stance towards KLA and its recognition as a factor in the conflict, DLK's position also shifted. |
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Others cite the end of the crack epidemic and demographic changes, including from immigration. |
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Blowing oxygen through molten pig iron lowers the carbon content of the alloy and changes it into steel. |
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Runway lighting and signage may need changes to provide clearance to the wings and avoid blast damage from the engines. |
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On 29 March 2009, Airbus CEO Thomas Enders told Der Spiegel magazine that the programme might need to be abandoned without changes. |
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These changes in fortune led to debate within the company about carrying on in the aircraft engine market. |
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France had no significant changes, while in Germany and Iceland the unemployment rate declined. |
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Moody was forced to sell his business, due to a shortage of capital, when the 1907 financial crisis fueled several changes in the markets. |
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Conceptually, inflation refers to the general trend of prices, not changes in any specific price. |
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These changes are not related to inflation, they reflect a shift in tastes. |
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Weighted pricing is a necessary means to measuring the impact of individual unit price changes on the economy's overall inflation. |
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Most inflation indices are calculated from weighted averages of selected price changes. |
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This problem can be overcome by including all available price changes in the calculation, and then choosing the median value. |
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Under these assumptions, the primary driver of the change in the general price level is changes in the quantity of money. |
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However, in the long run, changes in velocity are assumed to be determined by the evolution of the payments mechanism. |
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In 1965, Rose Friedman argued for the use of relative poverty claiming that the definition of poverty changes with general living standards. |
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For, as the motions are equally changed, the changes of the velocities made toward contrary parts are reciprocally proportional to the bodies. |
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Any of these changes might have an effect that is highly advantageous or highly disadvantageous, but large effects are rare. |
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Maxwell's equations describe how electric and magnetic fields are generated by charges, currents, and changes of each other. |
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Britain underwent enormous technological and industrial changes and advances particularly in the latter half of the 19th century. |
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The period of nationalisation saw sweeping changes in the national railway network. |
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Other changes to the British Transport Commission at the same time included the return of road haulage to the private sector. |
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Several changes were proposed including a shift to regional operators owning the track and trains for their regions. |
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In 2007, cabin crew threatened strike action over salary changes to be imposed by BA management. |
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In 2011, due to the merger with Iberia, British Airways announced changes to the Executive Club to maximise integration between the airlines. |
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Because volume changes with temperature and pressure, and pressure uses units of mass, the definition of a kilogram was changed. |
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These changes have a significant impact on the growing, breeding and migration seasons, as well as species abundance and diversity. |
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However, in the case of Spain changes were made at the time of transposing the Directive. |
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Climate change, demographic developments, urbanization, economic progress, social changes influence the water sector in many ways. |
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The fada serves to lengthen the sound of the vowels and in some cases also changes their quality. |
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Precipitation changes dramatically from one spot to the other, and diminishes very quickly eastward. |
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Diarrhoeal diseases were the result of poor hygiene, bad sanitation, and dietary changes. |
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As a result of these changes, large numbers of the working classes were able to participate in the consumer market for the first time. |
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The proposal was criticised by the UK parliament opposition parties for not proposing to implement any changes before the next general election. |
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Fiction was altered by these changes, including the creation of more difficult works. |
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We never heard about those changes coming, and were told everything would be staying the same. Typical mushroom syndrome from management again. |
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Music lessons in early childhood lead to changes in the brain that could improve its performance far into adulthood, researchers say. |
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Public taste has undergone fundamental changes, and the commercial arts can only flow where the paying public allows. |
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In object-oriented programming, the mutator function changes the value of the field that gives its name. |
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The song used gimmicks such as a vocal stutter to simulate the speech of a mod on amphetamines, and two key changes. |
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With the departure of the founding members, the band made several small changes to their image and sound. |
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In response to these changes going on in society, the movement of Realism emerged. |
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The only thing that changes is the iconography and, in some cases, the presence of a more critical attitude toward it. |
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Along with these changes, new forms of social coexistence and religion developed. |
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Other changes included having Arwen rescue Frodo, and the action sequence involving the cave troll. |
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Supporters of the series assert that it is a worthy interpretation of the book and that most of the changes were necessary. |
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This system was first launched in December 2007, becoming permanent in February 2008, and has undergone a few aesthetical changes since then. |
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One of his most important changes was the introduction of new technology and efficiency measures. |
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After behaviour has changed radically, small but quick changes of the phenotype follow to make the organism fitter to its changed goals. |
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However recent changes to the tennis calendar have seen the event moved back by two weeks cumulatively to begin in early July. |
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The new technical challenges of the Mountain Course forced changes on entrants and motorcycle manufacturers alike. |
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These changes are insignificant if a local datum is used, but are statistically significant if a global datum is used. |
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The King's intent was to respond to dissent while making as few actual changes in the status quo as possible. |
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However, the changes have been criticized as being too slow or merely cosmetic. |
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It has had several changes in its history, the most recent form is a plastic card meeting the ISO 7810 standard. |
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Lawrence River and Great Lakes, in accordance with modern surveying techniques, and thus accomplished several changes to the border. |
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The organisms in the riparian zone respond to changes in river channel location and patterns of flow. |
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They are complicated by climate change and changes in agricultural practices. |
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When changes to a habitat occur rapidly, animals do not have time to adjust. |
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She issued a stern warning against making changes too quickly. |
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Any changes to the plan require the agreement of everyone involved. |
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The following sections describe how each of these transforms can be used to make changes to objects on the artboard. |
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The autoscaling feature changes the x and y axis of your graph to fit the available data. |
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I had to back out the changes made to the computer when it became apparent that they had stopped it working properly. |
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Typical changes seen in the MRI are predominantly bifrontal T2-hyperintense white matter lesions with deep and subcortical involvement. |
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What changes will be wrought in the character and condition of mankind, as the millennium advances and rolls blissfully away. |
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I consider where more landmarks are needed and other changes for better flow and breadcrumbing. |
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That they have been exterminated by exceptional cataclysmal changes of the earth's surface has not been proved. |
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After several painful episodes, we've decided to adopt code review for all major changes. |
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The codifferentiation of myoepithelium and its basement membrane is associated with changes in the surrounding stroma. |
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In all notable changes and revolutions the contendents have been still made a prey to the third party. |
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As the currents were changing rapidly, the captain had to make many corrective course changes. |
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The Schwarzian measures how f changes the crossratio of infinitesimally close points. |
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Oil is denominated in dollars, so changes in the strength of the dollar affect oil prices everywhere. |
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There long had been a bias among researchers to think of the evolution of sexual dichromatism as driven by changes in male coloration. |
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The gas, however, may experience the same changes of volume and disgregation in another manner. |
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Many authors see a digital revolution taking place today and stress that this is a driving force behind many changes in companies. |
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As turning the logs will make a dull fire burn, so changes of study a dull brain. |
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The cyclic changes characterizing endometrioses are particularly apparent in endometriosis of the bladder. |
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Variation and changes in the trans fatty acid content of different foods, especially in processed foods, further complicate such estimates. |
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Additional changes that occur when water enters the lungs depend on whether the water is fresh or salt. |
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Five songs of spunky funkcore. Bouncy, peppy stuff with annoying tempo changes and whiny singing. |
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The manager was given her head to make whatever changes she might deem necessary in the structure of her department. |
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The level of glycin in the serum and the plasma of autistic patients does not show consistent changes. |
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Many politicians prefer to grandstand on hot-button issues rather than enact tough policy changes. |
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It was created in 2009 after constitutional changes, taking over the judicial functions of the House of Lords. |
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The digit in Fig 23 changes towards that class label which the classifier and the heatmapping implicitly perceive as the nearest neighbor. |
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Storm surges are caused by changes in barometric pressure combined with strong wind created wave action. |
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Changes in the formation of NADW have been linked to global climate changes in the past. |
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Following rapid climate changes at the end of the LGM this region was repopulated by Magdalenian culture. |
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Furthermore, it is clear from statistical analyses of annual tropical cyclones that these changes do not display multidecadal cyclicity. |
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The area was affected by sea level changes during the repeated Quaternary glaciations. |
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Such changes may have reduced the supply of usable timber and forced people to look at other materials. |
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Some scholars have argued that the appearance of complex or abstract language made these behavior changes possible. |
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Stress is a combination of duration, intensity, vowel quality, and sometimes changes in pitch. |
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English has undergone many historical sound changes, some of them affecting all varieties, and others affecting only a few. |
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Further complications have arisen through sound changes with which the orthography has not kept pace. |
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The precise start and end of the Industrial Revolution is still debated among historians, as is the pace of economic and social changes. |
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It is actively involved in the negotiation of treaty changes and defines the EU's policy agenda and strategies. |
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Throughout these changes, Yorkshire has continued to be recognised as a geographical territory and cultural region. |
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In the Norman period the Scottish church underwent a series of changes that led to new monastic orders and organisation. |
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For sound changes before and after the Old English period, see Phonological history of English. |
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The rebellion was eventually suppressed, but the social changes it promoted were already irreversible. |
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The Chronicle, as well as the distribution of copies to other centres of learning, may be a consequence of the changes Alfred introduced. |
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Revised editions appeared throughout the twentieth century to keep it up to date with changes in English usage. |
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These changes are the same as those involved in the operations of sensation, common sense, and thinking. |
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During this last glacial period, there were several changes between glacier advance and retreat. |
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Their development, diffusion and long range changes are determined by the great river systems. |
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The relative nutritional benefits and drawbacks of these dietary changes and their overall impact on early societal development is still debated. |
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During the Late Neolithic, British society underwent another series of major changes. |
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Major changes in design did not become common until the Age of Enlightenment, when there was rapid progress in design. |
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The influence is visible even in the law of persons or of the family, which is traditionally the part of the law that changes least. |
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The decline of Roman Britain in early fifth century AD led to significant social and economic changes all over Britain. |
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The extent to which this cultural and linguistic change was accompanied by wholesale changes in the population is still a matter of discussion. |
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A review of the changes in the Brythonic language during this period is given by Kenneth Jackson. |
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Sjostrom's game is predicated on strong skating. He accelerates in a heartbeat with a lightning quick stride and changes direction smoothly. |
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They kept the framework of government but made changes in the personnel, although at first the new king attempted to keep some natives in office. |
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Sayles, see the changes brought about by the Conquest as much less radical than Southern suggests. |
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Henry's reign saw significant legal changes, particularly in England and Normandy. |
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However, migration of workers from the ineligible population into the eligible population also changes the composition of the ineligibles. |
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Yet it was not in the upper, but in the lower house that the greatest changes took place, with the expanding political role of the Commons. |
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These changes brought the customary rights of lay rulers such as John over ecclesiastical appointments into question. |
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The region has experienced extensive changes over the years, starting after the battle. |
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Domestically, Henry is known for his radical changes to the English Constitution, ushering in the theory of the divine right of kings to England. |
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Please be sure to keep your manager and the customer contacts in the loop if you must make changes. |
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Data from ionograms may be used to measure changes in the Earth's ionosphere due to space weather events. |
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In 1657, Oliver Cromwell renewed the charter of 1609, and brought about minor changes in the holding of the company. |
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Since that date, a few further changes have been introduced to the Oxford standard text. |
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The 1982 Canada Act passed by the British parliament ended the need for British involvement in changes to the Canadian constitution. |
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Such changes might include a closing factory, market manipulation, the signing of international trade treaties, new natural gas regulation, etc. |
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In the 19th century, Manchester featured in works highlighting the changes that industrialisation had brought to Britain. |
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These changes contributed to the development of nationalism and the nation state. |
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It is likely to be affected mainly by changes in the age distribution of the population. |
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Romania's entry into the War in August 1916 provoked major changes for the Germans. |
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When urgent changes and improvements needed to be made, Dowding seemed reluctant to act quickly. |
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Since the npr changes with engine thrust setting and flight speed this is seldom the case. |
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Note that due to methodological changes, these figures are not directly comparable. |
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These changes have given rise to controversy within the medical professions, the news media and the public. |
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Bhumibol has reigned through several political changes in the Thai government. |
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The 1885 legislation detailed boundary changes but did not detail boundaries for all constituencies. |
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Between the 2009 and 2014 elections, there were various changes to the breakdown of UK members. |
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The proposals called for changes in procedures in the House of Commons for the passage of bills relating only to England. |
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The Commission also proposed a number of changes to procedure, including allocating specific parliamentary time to proposals for England. |
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The changes were debated by the Third Delegated Legislation Committee in January 2016, rather than in the Commons. |
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Phil Wheatley blamed budget cuts and excessive changes in government policy for the state of prisons. |
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It was renamed but otherwise unreformed by the changes in local government that occurred in 1974 in the rest of England outside Greater London. |
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At the end of the last Ice Age the Bristol Channel was dry land, but subsequently the sea level rose, resulting in major coastal changes. |
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Although there were substantial changes in society and political structures, the break with classical antiquity was not complete. |
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Over time, the design of the uniform changed in line with changes made to army uniform. |
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Some relatively minor changes have been made to the boundaries of boroughs since 1965, and two have changed their names. |
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The main purpose of these changes was to tidy up the boundary where it had been rendered obsolete by changes in the urban landscape. |
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How much the deforestation was caused by climatic changes and how much by human activity is uncertain. |
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The major changes during the last 2 million years were brought about by several recent ice ages. |
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In the 1990s further population growth led to more political changes on a local level. |
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Because it makes predictions about price changes rather than price levels, relative PPP is still a useful concept. |
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Early designs also respond very slowly to power changes, a fact that killed many experienced pilots when they attempted the transition to jets. |
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Many of the changes were applied to all three variants to maintain high levels of commonality. |
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Offered for the Block 4 configuration, it fits into the same area as the baseline EOTS with minimal changes while preserving stealth features. |
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These changes resulted in increased procurement prices, and increased the likelihood of further cuts. |
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By contrast, Priestley preferred to observe qualitative changes in heat, color, and particularly volume. |
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Crick suggested that it might be possible to find chemical changes in the brain that were molecular correlates of the act of prayer. |
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The bridge was built to designs based on Brunel's, but with significant changes. |
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The governor could not actually hold a set speed, because it would assume a new constant speed in response to load changes. |
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The processes by which the changes occur, from one generation to another, are called evolutionary processes or mechanisms. |
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Mechanisms that can lead to changes in allele frequencies include natural selection, genetic drift, genetic hitchhiking, mutation and gene flow. |
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Hence, in this model, most genetic changes in a population are the result of constant mutation pressure and genetic drift. |
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The presence or absence of gene flow fundamentally changes the course of evolution. |
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It is now becoming clear that most alterations in the form of organisms are due to changes in a small set of conserved genes. |
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These changes in the second species then, in turn, cause new adaptations in the first species. |
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Selection under these conditions can produce very rapid changes in the appearance and behaviour of organisms. |
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Finally, in sympatric speciation species diverge without geographic isolation or changes in habitat. |
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No obvious changes in morphology or cellular organisation occurred in these organisms over the next few billion years. |
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If the speed is constant, only multiplication is needed, but if the speed changes, a more powerful method of finding the distance is necessary. |
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In biology, population dynamics starts with reproduction and death rates to model population changes. |
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The railways entered a slow decline owing to a lack of investment and changes in transport policy and lifestyles. |
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Though there were few initial changes to the service, usage increased and the network became profitable. |
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The boundaries of these periods are uncertain, as the changes between them are gradual. |
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In addition, the dates of these changes demonstrated in Britain are generally different from those of Continental Europe. |
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It is likely that these environmental changes were accompanied by social changes. |
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Antoninus made few initial changes when he became emperor, leaving intact as far as possible the arrangements instituted by Hadrian. |
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The changes on coinage and military expenditures were the root of the financial crisis that marked the Crisis of the Third Century. |
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Recently a number of linguists have argued that many of the grammar changes observed in English were due to a Brythonic influence. |
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The following is a summary of the major sound changes affecting vowels in chronological order. |
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Middle English developed out of Late Old English, seeing many dramatic changes in its grammar, pronunciation and orthography. |
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This method studies both changes in markets and their interactions leading towards equilibrium. |
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Editing may also involve structural changes and requests for more information. |
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The 21st century has brought some new technological changes to the publishing industry. |
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Before the 2010 boundary changes Cornwall had five constituencies all of which were won by Liberal Democrats in the 2005 general election. |
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This is mainly due to extreme phonetic changes since the Old French period, without a corresponding change in spelling. |
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Of those most critical of the Church's direction, some chose to stay and try to make constructive changes from within the Anglican Church. |
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This organization later went through its own changes, spinning off other conventions. |
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Hinduism underwent profound changes, aided in part by teachers such as Ramanuja, Madhva, and Chaitanya. |
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Each prospectus isn't fixed, but changes as schedules are changed or documents are late. |
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The regulatory body for sixth form colleges was already DfE prior to the 2016 changes. |
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The critical mindset imparted by humanism was imperative for changes in universities and scholarship. |
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They also approve new programs of instruction and cancel or make changes in existing programs. |
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This has led to changes in lending policy at many major American universities. |
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Between 1997 and 2000 the site underwent several revamps and changes of strategy, as the FT Group and Pearson reacted to changes online. |
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Due to changes in function and design since the tower's construction, except for the chapel little is left of the original interior. |
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