| Bone marrow cells exhibited chromosome aberrations, aneuploidy, and changes in the mitotic index. |
| True non-disjunction as a mechanism causing aneuploidy was separately assessed when a bivalent was found in a set of metaphase II chromosomes. |
| In view of the role played by aneuploidy in carcinogenesis and in human reproductive failure, this omission is perhaps surprising. |
| The most direct way to assess chromosomal aneuploidy is to evaluate chromosome numbers in metaphase cells. |
| In principle, non-disjunction during spermatogenesis could lead to aneuploidy, which might cause fetal death. |
| There may be specific types of mutagens, e.g. aneuploidy inducers, which act preferentially during meiotic gametogenesis stages. |
