| Two of these, adenylate kinase and purine nucleoside phosphorylase, contain potential critical building blocks. |
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| Cidofovir is a nucleoside phosphonate analogue that inhibits herpes virus DNA polymerases. |
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| Nonpolar nucleoside isosteres have proven broadly useful in the study of DNA replication by a wide variety of polymerase enzymes. |
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| In January 2001 the Food and Drug Administration issued a special warning to pregnant women taking nucleoside analogues ddI and d4T after three women died. |
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| Baraclude contains the medicinal ingredient entecavir which is a guanosine nucleoside analogue. |
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| Clofarabine, a type of drug called a purine nucleoside antimetabolite, works by blocking the production and repair of DNA, the building blocks of genes. |
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| Neither of the two NIH scientists knew the name or chemical compound of AZT at the time or that it was a nucleoside analogue. |
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| We assessed the clearance of endogenous pseudouridine in humans to evaluate the potential use of this modified nucleoside as a marker of glomerular filtration rate. |
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| Chemists and pharmacists here explore some of the techniques used to synthesize nucleoside analogues. |
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| A nucleobase linked to a sugar is called a nucleoside and a base linked to a sugar and one or more phosphate groups is called a nucleotide. |
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| Polymerases are enzymes that synthesize polynucleotide chains from nucleoside triphosphates. |
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| Approved March 14, 1996 for use alone or in combination with nucleoside analogues for the treatment of HIV infection in adults. |
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| An Escherichiacoli system expressing human deoxyribonucleoside salvage enzymes for evaluation of potential antiproliferative nucleoside analogs. |
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| A major factor in the resistance of cells to antifolate cancer treatment involves nucleoside salvage from the extracellular media. |
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| Adenosine is antagonized competitively by methylxanthines such as caffeine and theophylline, and potentiated by blockers of nucleoside transport such as dipyridamole. |
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| Acyclovir, a synthetic acyclic purine nucleoside analog, is a substrate with a high degree of specificity for herpes simplex and varicella-zoster-specified thymidine kinase. |
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| For example, an enzyme called nucleoside phosphorylase serves this role when cells switch to synthesizing nucleotides from recycled purines instead of from new starting materials. |
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| Use of an acylated derivative of uridine, cytidine, deoxycytidine or deoxyuridine in the manufacture of a medicament for preventing or treating toxicity due to a pyrimidine nucleoside analog. |
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| Previously treated with three classes of antiretrovirals: nucleoside analogues, non-nucleoside reverse transcriptase inhibitors and protease inhibitors. |
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| Obesity and prolonged nucleoside exposure may be risk factors. |
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| As more people develop resistance to protease inhibitors, nucleoside reverse transcriptase inhibitors and non-nucleoside reverse transcriptase inhibitors, other therapeutic options become indispensable. |
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| The drug is similar to nucleoside analogs such as ddI but requires less intracellular processing to reach its active state. |
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| Two large studies of HIV patients found a link between treatment with the nucleoside Ziagen and a higher risk of heart attacks and other heart disease. |
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| Ed4T, which was developed by Yale University, Kagoshima University and Showa University, is a nucleoside reverse transcriptase inhibitor with enhanced anti-HIV-1 activity. |
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| Reverset is a nucleoside analog reverse transcriptase inhibitor that is being developed as a once-daily oral HIV therapy by Incyte Corporation and Pharmasset, Inc. |
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| Nucleoside analog reverse transcriptase inhibitors, the first antiretroviral agents to be introduced to the market back in 1987, remain a mainstay of anti-HIV therapy. |
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