| The data was therefore convoluted with a profile that mimics the image of a microtubule to filter out the vertical coordinate. |
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| If microfilaments antagonize microtubules, this uneven distribution of microfilaments should affect microtubule morphology. |
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| It was assumed that each kinetochore remained attached to the tip of its microtubule throughout the duration of the simulation. |
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| It is the sperm basal body that serves as a centriole in the zygotic microtubule organizing center. |
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| The front head attaches to a microtubule with a displacement toward the plus end of the microtubule. |
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| In mitosis, microtubule spindle fibers attach to the kinetochores, pulling the chromatids apart. |
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| These solutions show that the dynamics of motion is dramatically slowed down if one end of a microtubule is fixed instead of free. |
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| The ultrastructure of normal cilia consists of nine outer microtubule pairs and two single central microtubules. |
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| Kinetochore proteins bind to a microtubule spindle to keep chromosomes segregated during cell division. |
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| Such techniques can provide us with only the information of microtubule displacement in a plane vertical to the optical axis. |
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| The length of the longest microtubule bundle in monopolar tubulin arrays was measured microscopically. |
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| Using cytologically tagged chromosomes, we established a role for the microtubule motor dynein in meiotic chromosome segregation. |
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| The astral microtubule arrays around the centrosomes, like the nuclei, are visible as areas that are largely devoid of yolk granules. |
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| These observations indicate that the MTOCs of the two haploid nuclei failed to fuse, remaining as microtubule nucleating centers. |
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| This model predicts that upregulated 14-3-3 causes abnormal tau phosphorylation, tau aggregation, microtubule disruption, and neurodegeneration. |
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| Actin dynamics and microtubule polymerisation can be monitored simultaneously in a living neuronal cell during polarization. |
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| The centriole is a cylindrical structure 0.4 μm long and 0.2 μm in diameter, composed of microtubule triplets that display ninefold radial symmetry. |
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| In animal cells during mitosis and interphase, microtubule growth occurs at plus ends, and microtubule assembly is dominated by plus-end dynamic instability. |
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| Kinetochore microtubule bundles link sister chromosomes to the poles. |
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| An interphase cell contains four microtubule rootlets arranged in a cruciate array originating at the basal bodies and radiating outward, just under the plasma membrane. |
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| Disruption of the microtubule network significantly weakens the elastic response, and the disassembly of actin filaments completely prevents gelation. |
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| Dithiopyr is an inhibitor of microtubule assembly, inhibiting plant cell divisions. |
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| Examination of this and other images indicated that a denser microtubule network was associated with the epitheca than the hypotheca. |
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| Targeted compounds were evaluated for antimitotic microtubule destabilizing activity using a phenotypic sea urchin embryo assay. |
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| The two poles of the mitotic spindle are occupied by centrosomes, which organize the microtubule arrays. |
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| Their ability to directly regulate microtubule organization and polymerization dynamics places them in a new class of chemotherapeutic targets. |
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| The dynein arms on the opposite side of the dynein cross-bridge are then activated and slide up the opposite microtubule. |
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| At this junction, each pair of microtubules is joined by an additional microtubule, forming nine triplets. |
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| The isolated cells were further stained with fluorescent dye and found that spindle and microtubule formation has occurred in the treated cells. |
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| On one hand, angiosperm cells lack centrosomes as microtubule organizing centres and are missing the contractile ring which serves as a tool for cytokinesis in animal cells. |
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| At metaphase, centrosomes initiate the bipolar microtubule spindle. |
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| Failure of Eg5 function leads to cell cycle arrest in mitosis with monoastral microtubule arrays. |
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| A new model for microtubule dynamic instability. |
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| According to these authors, however, some aluminum compounds appear able to produce chromosomal anomalies in plant material, probably as a result of an interference with microtubule polymerisation. |
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| In the presence of ATP, dynein molecules are activated, and the flagellum bends as dynein arms on one side of a dynein cross-bridge become activated and move up the microtubule. |
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| Dr Howard, together with Henry Hess, of the University of Washington, in Seattle, has devised a way to transfer tiny plastic beads from a moving microtubule to a fixed one. |
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| The top image illustrates how mitochondria may be anchored within the cell through actin cytoskeletal elements, with long range movement facilitated by kinesins and dyneins along microtubule tracks. |
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| Platinum compounds, antimetabolites and microtubule disruptors and topoisomerase inhibitors are often used for chemotherapy, usually in combination, and side effects can limit therapy. |
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| Movie 1: movement of a magnetic endosome on a fluorescent microtubule. |
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| This presentation concluded that Kip3D localizes to ends of mitotic spindle microtubules and is a microtubule depolymerizing kinesin. |
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| In the gel state, it was further hypothesized that the water electrical dipoles are oriented in the same direction, along the outer edge of the microtubule tubulin subunits. |
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| Experimentally disrupting microtubule dynamics in the species Strongylocentrotus pupuratus by applying colchicine stalls the ingression of PMCs, but does not inhibit it. |
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| Docetaxel, a microtubule stabilizing agent, has been reported to interfere with spindle microtubule dynamics causing mitotic cell cycle arrest and apoptosis. |
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| Normally, tau protein is involved in microtubule formation, which acts as a brain cell's transportation system for carrying nutrients in and waste out. |
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| Microtubule drugs are widely used in cancer chemotherapy due to their cytostatic effects. |
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