| These data further support the idea that the observed micronuclei result from preferential exclusion of acentric DNA fragments. |
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| Frequencies of nuclear abnormalities other than micronuclei, such as binucleates, karyorrhexis and karyolysis, were also evaluated. |
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| These tests score either chromosomal structural aberrations at metaphase or micronuclei at interphase. |
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| Diet is an important variable in determining DNA damage biomarkers, specifically micronuclei. |
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| Besides amitosis, cold-pretreatment also induced some abnormal mitotic behavior leading to the formation of micronuclei. |
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| The results showed no difference in presence of micronuclei in the exposed vs. the unexposed groups. |
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| Visualisation of micronuclei is facilitated in these cells because they lack a main nucleus. |
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| It is important to examine other biomarkers, such as chromosome aberrations and micronuclei, that relate to the damage still present after cellular processing. |
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| The numbers of observed micronuclei are presented in both tabular and graphical form but the data appear to be inconsistent between the two forms of presentation. |
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| The micronuclei of wild-type pairs provided a reliable diploid standard to quantify the macronuclear DNA content of exconjugants by cytophotometry. |
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| Additional information may be obtained by scoring mature erythrocytes for micronuclei. |
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| These include identification of the presence or absence of a kinetochore or centromeric DNA in the micronuclei. |
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| The number of macronuclei and micronuclei formed is dependent on the species and remains the same as the original number. |
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| Positive controls should produce micronuclei in vivo at exposure levels expected to give a detectable increase over background. |
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| Over the past two decades, numerous studies have been undertaken using the micronuclei test of higher plants to detect the mutagenicity of water, air, and pure chemicals. |
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| The purpose of the micronucleus test is to identify substances that cause cytogenetic damage which results in the formation of micronuclei containing lagging chromosome fragments or whole chromosomes. |
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| Negative results indicate that, under the test conditions, the test substance does not produce micronuclei in the immature erythrocytes of the test species. |
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| Although micronuclei can arise from lagging whole chromosomes following interaction of a compound with the spindle apparatus, the micronucleus test may not detect all aneuploidy inducers. |
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| The presence of micronuclei in each cell was confirmed under 1,000x magnification. |
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| The extent of DNA damage was evaluated by the frequency of micronuclei in cultured peripheral blood lymphocytes and by comet assay. |
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| All chemicals were detected as inducers of micronuclei. |
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| During logarithmic growth, when there are micronuclei mitosis and macronuclei amitosis, and starvation condition, CYC2 gene doesn't express at all. |
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| At the end of each exposure period, peripheral blood smears were examined for immature erythrocytes, detected by polychromasia, and for micronuclei. |
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| Lanthanum chloride did not induce micronuclei in the polychromatic erythrocytes of the bone marrow and did not induce unscheduled DNA synthesis in the liver. |
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| Positive results in the micronucleus test indicate that the substance induces micronuclei which are the result of chromosomal damage or damage to the mitotic apparatus in the erythroblasts of the test species. |
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| No drug-related increases in micronuclei were found. Hence, under the conditions used, the drug does not induce chromosome breaks or mitotic non-disjunctions in mouse bone marrow cells. |
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| Frequency of micronuclei in lymphocytes from a group of floriculturists exposed to pesticides. |
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| The results of the micronucleus test indicated that clodronate disodium, at the doses used, did not induce the formation of micronuclei in the marrow of Swiss mice and therefore was not mutagenic in the test system. |
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| All but one of these haploid micronuclei disintegrate. |
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| Ciliates have one or more macronuclei and from one to several micronuclei. |
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| The micronucleus undergoes two mitotic divisions to produce four micronuclei: two of these will form the new micronuclei of the cell, and two are destined to become the macronucleus. |
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| A series of nuclear divisions of the micronuclei in each ciliate then ensues, including meiosis, during which a number of haploid micronuclei are produced in both cells. |
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| When animals are treated continuously for four weeks or more, at least 2 000 mature erythrocytes per animal can also be scored for the incidence of micronuclei. |
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| Preparations are analysed for the presence of micronuclei. |
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| Y chromosome aneuploidy, micronuclei, kinetochores and aging in men. |
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| Micronuclei may originate from acentric chromosome fragments or whole chromosomes lagging behind during cell division. |
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| Micronuclei are observed in binucleated cells in which cytokinesis has been inhibited. |
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| Micronuclei can arise from acentric chromosome fragments or whole chromosomes that have not been incorporated in the main nuclei at cell division. |
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| Micronuclei are chromosomes or chromosomal fragments that fail to incorporate into either of the two daughter nuclei after karyokinesis. |
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| Micronuclei are tiny pieces of DNA that are left over from when a cell replicates and fails to copy its genetic code properly. |
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| Micronuclei are composed of chromosomes or fragments of chromosomes that provide an indicator of chromosomal damage. |
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