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What is the opposite of panaceas?

Need antonyms for panaceas? Here's a list of opposite words from our thesaurus that you can use instead.

Noun
Issues or things that need to be resolved
“The company is struggling to address several critical problems.”
Noun
Issues or problems requiring resolution
“There were many political and economic challenges in the region that had to be addressed.”
Noun
Opposite of plural for a solution or remedy for all difficulties or diseases
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