vexation, aggravation, pestering, bedevilment, harassment, annoyance, harrying, importunity, bugging, teasing, bothering, disturbance, problem, irritation, perturbation, agitation, provocation, exasperation, persecution, hassle, torment, trouble, badgering, distraction, molestation, provoking, irking, vexing, annoying, disturbing, needling, disruption, interruption, interference, confusion, stirring, ruffling, hindrance, roiling, whisking, derangement, inconvenience, convulsion, bother, intrusion, dislocation, nuisance, pressure, pressurization, coercion … more

hurdles, challenges, difficulties, adversities, complications, dilemmas, hindrances, obstacles, problems, catches, glitches, hitches, issues, obstructions, predicaments, quandaries, setbacks, snags, hassles, headaches, misfortunes, pickles, puzzles, troubles, worriments, messes, worries, plights, dilemmata, problemata, disputes, burdens, questions, perplexities, doubts, squeezes, scrapes, boxes, cans of worms, hot water, catch-22s, drawbacks, downsides, bugbears, counts, crunches, disagreements, hornets' nests, habits, upsets … more