(intransitive, US, slang) To exhibit symptoms of methamphetamine abuse, such as extreme nervousness, compulsiveness, erratic motion, excitability; possibly a blend of twitch and freak.
(intransitive, US, slang) To exhibit extreme nervousness, evasiveness when confronted by law enforcement or other authority (e.g., customs agents, border patrol, teacher, etc.), mimicking methamphetamine abuse symptoms.