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What does screw up mean?

Looking for the meaning or definition of the word screw up? Here's what it means.

Verb
  1. (transitive) To tighten or secure with screws.
  2. (transitive) To raise (rent, fees, etc.) to extortionate levels.
  3. (transitive) To twist into a contorted state
  4. (transitive, dated) To squint.
  5. (transitive, colloquial) To make a mess of; to ruin.
  6. (intransitive, colloquial) To blunder; to make a mistake.
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