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What is a protoporphyrin?

What is a protoporphyrin? Here are some definitions.

Noun
  1. (biochemistry) Any porphyrin that lacks a central metal ion
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Examples
Concentration of protoporphyrin IX in cancer tissues and blood in patients with colorectal cancer at early stage.
All laboratories submitting results for erythrocyte protoporphyrin fractions found predominantly free protoporphyrin in the erythropoietic protoporphyria patient.
Four molecules of this porphyrin precursor cyclize and undergo several side-chain modifications to yield the tetrapyrrole protoporphyrin.
Although protoporphyrin was associated with a large proportion of our abnormal measurements, it was not found to be diagnostically useful.
Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels.

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