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What is a phosphodiesterase?

What is a phosphodiesterase? Here are some definitions.

Noun
  1. (biochemistry) any of a family of enzymes that catalyze the cleavage of phosphodiester links in nucleic acids
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Examples
Selective phosphodiesterase inhibitors such as roflumilast are not registered for use in acute asthma.
The two proteins added today are phosphodiesterase IV and peroxisome proliferator-activated receptor delta, both are active targets of structure based drug design.
Cyclo AMP phosphodiesterase is inhibited and an anti-oxidative effect was proven for scopoletine, isofraxin and fraxin.
Calf spleen phosphodiesterase, snake venom phosphodiesterase and alkaline phosphatase were from Roche Molecular Biochemicals.
Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats.
In unstimulated ORNs, both adenylate cyclase and cAMP phosphodiesterase are active.

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