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What does paracrine mean?

Looking for the meaning or definition of the word paracrine? Here's what it means.

Adjective
  1. Describing a hormone or other secretion released from endocrine cells into the surrounding tissue rather than into the bloodstream.
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Examples
Stromal antiapoptotic paracrine loop in perineural invasion of prostatic carcinoma.
In the pancreas, somatostatin acts a paracrine inhibitor of other pancreatic hormones and thus also has systemic effects.
Numerous studies have examined the role of paracrine interactions within islets and the importance of gap junctions to islet stimulus-secretion coupling.
The cells also use paracrine signalling to control the activity of each other.
To assess the possible involvement of a paracrine mechanism, normal human keratinocytes were exposed to SSR and culture medium was collected 24 h later.
In in vitro studies we identified a paracrine linkage between keratinocytes and fibroblasts that leads to wrinkle formation through the upregulation of fibroblast elastases.

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