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What is pachyderma?

What is pachyderma? Here are some definitions.

Noun
  1. (medicine) Abnormal thickening of the skin.
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Examples
The cool-water assemblage was dominated by another species, which rejoiced in the glorious name Neogloboquadrina pachyderma.
Hyla robertsorum, pachyderma, and crassa are the most aquatic members of the group.
In the Hyla bistincta group, Hyla pachyderma is unique in having enlarged nuptial spines.

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