| Oligospermia was only observed in one animal. |
| In patients with azoospermia or severe oligospermia, the karyotype should be determined because of the increased incidence of karyotypic abnormalities in this population. |
| In high-dose males, a decrease in testes weights, testicular atrophy and atrophy of the seminal vesicles and prostate, aspermia or oligospermia in the epididymides were observed. |
| In men with oligospermia it increases concentration of luteinizing hormone and follicle-stimulating hormone, testosterone and estrogen in the blood serum. |
| The most common adverse reactions associated with sulfasalazine are anorexia, headache, nausea, vomiting, gastric distress, and apparently reversible oligospermia. |
| Men with nonobstructive azoospermia and severe ogliospermia should be informed of the potential genetic abnormalities associated with azoospermia or severe oligospermia. |
