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What does nonsynonymous mean?

Looking for the meaning or definition of the word nonsynonymous? Here's what it means.

Adjective
  1. Not synonymous.
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This difference indicates a striking increase in selection against nonsynonymous substitutions in oncogenes and tumor suppressor genes.
By contrast, at least some nonsynonymous mutations are expected to be strongly deleterious because they damage protein structure and thereby render the cell nonviable.
The results reveal 23 nonsynonymous changes and 127 invariant sites in total in the hinge region.

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