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What does no matter mean?

Looking for the meaning or definition of the word no matter? Here's what it means.

Adverb
  1. Irrespective of, regardless of, in spite of.
  2. It doesn't matter, it's unimportant, it doesn't make any difference.
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Examples
Show up early, because no matter what time you go, there will be an interminable wait.
Modem science, no matter how theoretical, speculative and abstract, strives finally for empirical evidence to test and confirm the truth of its claims.
You all know those kinds of drunks that no matter how tanked they get, they still seem to keep their wits.
The truly outstanding athlete always fights his way to the top, no matter what the odds.
The security of any single organization is only as strong as that of the weakest link in the chain, no matter how large or small.
He's already been in cell 118 for five hours and I decide, no matter what, I'm going to not have the same look on my face when I'm jettisoned.

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