| Hyponatraemia occurs as a result of dehydration, nephrotoxicity, or occasionally inappropriate antidiuretic hormone secretion. |
| Caution about potential nephrotoxicity has been noted above. |
| If renal failure develops in patients treated with Asacol it can be caused by mesalazine-induced nephrotoxicity. |
| Such accumulation, excessive peak concentrations, advanced age, and cumulative dose may contribute to ototoxicity and nephrotoxicity. |
| Vancomycin hydrochloride should be used with care in patients with renal insufficiency because of its ototoxicity and nephrotoxicity. |
| Use of these materials may decrease reactions such as nausea, flushing and bradycardia, but there is no apparent reduction of anaphylactic reactions or nephrotoxicity. |
