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What does exasperation mean?

Looking for the meaning or definition of the word exasperation? Here's what it means.

Noun
  1. The act of exasperating or the state of being exasperated; irritation; keen or bitter anger.
  2. Increase of violence or malignity; aggravation; exacerbation.
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Examples
In exasperation, Hoxsey attempted an end run by approaching the National Cancer Institute.
Finally, the detective sighed in exasperation, and ordered his partner to take the teacher away, cuffing his hands from behind.
The dejected Farmworkers' union chief induna tried in exasperation to explain exactly what he threatened to do and what not.
And there is no doubting the cabinet minister's exasperation with the chardonnay socialist classes.
There was also a half hour of exasperation when I temporarily mislaid my handheld somewhere in the hospital.
Despite the exclamation mark, he talks in the flat, imperturbable vowels of Sussex, his voice rising not so much in volume as in exasperation.

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