What is a cafard?

What is a cafard? Here are some definitions.

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They mustn't go to the places where the cafard would take him.
There hasn't been a case of cafard on this ship since I've been ship's doctor.
The germ of madness, of tragedy, always lies hidden in the cafard.
The cafard is strong on me, and the futility of my drifting existence.
Some of the crew have been showing signs of cafard, which is a space sickness generated by long stretches in space without relief or suitable activities of interest.
You've got cafard, and we must make sure you have the best thing done for you.

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