Two controlled trials have directly compared benztropine and propranolol in antipsychotic-induced akathisia. |
Short term treatment with antipsychotic drugs carries a significant risk of sedation, acute dystonias, akathisia, and parkinsonism. |
Side effects included dystonic reactions, acute dyskinesia, Parkinsonism, akathisia, and autonomic and cardiovascular symptoms. |
While not depicted here, it is suggested that the inhibitory input to these DA pathways produces the overt and covert restlessness characteristic of akathisia. |
It can be difficult to distinguish akathisia from the agitation that is often present in patients with dementia. |
Propranolol may help physical symptoms such as racing heart and akathisia but has no effect on psychic components of anxiety. |