| The acetyl-CoA then is used to acetylate histones, resulting in gene activation. |
| Previous reports have employed approximately a 1000-fold molar excess of acetic anhydride to acetylate solvent accessible lysine residues. |
| For instance, the enzymes that acetylate newly synthesised histones represent potential targets for novel anti-neoplastic agents. |
| A decade ago, histone acetyl transferases were first reported to acetylate the tumour suppressor p53, leading to the notion that HATs and HDACs are not just for histones. |
| Scientists have identified enzymes that acetylate, deacetylate, phosphorylate, dephosphorylate, and methylate histones. |
| In addition to histones, some HATs can acetylate non-histone proteins, suggesting multiple roles for these enzymes. |
