| Tumour necrosis factor or TNF plays a key role in inflammation. |
| Adalimumab is an IgG monoclonal antibody specific for TNF-alpha, thereby blocking its interaction with cell surface TNF receptors. |
| The active principles are either a soluble TNF receptor that binds to and inactivates TNF-alpha, or an anti-TNF-alpha monoclonal antibody. |
| Fortunately, many people with psoriatic arthritis have responded well to the newer biologic therapies that target the molecule TNF alpha. |
| Having too much TNF is being linked to many hitherto-unexplained inflammatory conditions, such as rheumatoid arthritis, multiple sclerosis, leprosy and the rejection syndrome 'graft versus host' disease. |
| Hematologic Reactions Rare reports of pancytopenia, including aplastic anemia, have been reported with TNF blockers. |
