| While remaining innocuous to the normal tissues, the prodrug is converted to the cytotoxin by the enzyme localised at the tumour. |
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| This involves gene transfer of an enzyme into tumour cells, which converts an inactive prodrug into a toxic metabolite, leading to cell death. |
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| Valacyclovir, a prodrug that metabolizes to acyclovir, has better bioavailability and requires less frequent dosing than acyclovir. |
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| They waited a bit to give the unbound nanobodies time to filter out of the body, then injected the prodrug. |
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| Cefuroxime axetil is the ester prodrug of cefuroxime sodium, suitable for oral administration. |
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| Codeine, a prodrug, depends on P450 metabolism to morphine for its analgesic effect. |
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| A second important aspect of the invention is to have the second binding head capture or contain an enzyme that activates a prodrug substrate. |
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| The catalytic enzyme is regenerated after each activation and able to react anew with additional prodrug molecules. |
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| An ester prodrug was shown to increase the bioavailability of MPA following oral administration. |
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| A prodrug is considered to have the same mechanism of action as its active metabolite. |
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| No cataract was observed in non-diabetic rats with or without treatment of the prodrug. |
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| Its prodrug, prepared as an eye drop and applied to diabetic rats, significantly delayed the initiation of the diabetic cataract. |
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| Consequently, BELLUS Health is forging ahead with the development of the NRM8499 prodrug candidate. |
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| Dipivalyl D-isoproterenol is a prodrug of D-isoproterenol that can be administered topically by eye drop. |
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| The antihistamine loratidine is one example of a prodrug that must be activated by liver enzymes to be effective, the researchers pointed out in their paper. |
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| Administered by conventional eye drop as a dipivalyl prodrug derivative, this agent could prevent and treat glycation-related ocular pathologies such as diabetic retinopathy. |
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| Fosamprenavir is a prodrug of amprenavir, and is converted into amprenavir in the body. |
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| Scavenging of reactive oxygen and nitrogen species by the prodrug sulfasalazine and its metabolites 5-aminosalicylic acid and sulfapyridine. |
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| Famciclovir is a prodrug that is converted in vivo to penciclovir, the active antiviral agent. |
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| Olmesartan medoxomil is a prodrug whose active metabolite, olmesartan, blocks the vasoconstrictor effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in vascular smooth muscle. |
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| Super-Leu-Dox consists of doxorubicin conjugated to a proprietary prodrug peptide. |
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| Continuous eye drop administration of its prodrug will ultimately prevent glycation allowing for ocular protection from diabetic retinopathy and other diabetes-and age-related complications. |
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| Viramidine is a ribavirin prodrug that offers the advantage of being specifically transformed by the liver cells which should diminish the normal toxicity of ribavirin on blood cells. |
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| The use of a prodrug activated by enzymatic aromatic hydroxylation having the formula of either one of Formulae VII or XII: in the manufacture of a medicament for the treatment of a tumour. |
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| The form available in South Africa is a prodrug, colistimethate sodium or colistin methanesulfonate, which makes a bolus dose necessary to achieve therapeutic effect. |
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| GenSpera's technology platform combines a powerful, plant-derived cytotoxin with a prodrug delivery system that targets release of the drug within the tumor. |
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| In France, the antidrug law forbids all forms of prodrug propaganda. |
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