How to use necrosis in a sentence

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Sentence Examples Infliximab cross links tumour necrosis factor bound to T cells, thus inactivating or destroying it. These 4 specimens were extremely fibrotic, exhibited marked necrosis, or were small lesions that were difficult to scrape. Liver biopsies from the jaundiced patients were similar, with duct necrosis, ductular proliferation, and portal inflammation. The present work presents a mechanism leading to cell death, necrosis at the tissue level. At autopsy, these animals presented acute tubular necrosis, esteatosis, carditis, and diffuse alveolar damage. In the liver, varying degrees of centrilobular necrosis and steatosis and a mild portal inflammatory infiltrate were seen in the SARS patients. Avascular necrosis of the capitate bone is a rare clinical entity, and it is usually a sequel to serious trauma. Mitosis, size of tumour, necrosis and pleomorphism are thought to be prognostic factors for aggressiveness of solitary fibrous tumours. Liver cell necrosis is indicated by highly elevated serum liver transaminase levels. As the disease progresses, necrosis and liver cell death may lead to fibrosis. Vasopressin should be infused through a central catheter because peripheral extravasation could cause tissue necrosis and gangrene. This shows an infiltration of polymorphonuclear leukocytes with foci of necrosis, thrombosis, and hemorrhage. Circulating concentrations of the cytokine tumour necrosis factor are increased in cachectic patients with chronic heart failure. Single cells will be found in nephritis, acute tubular necrosis, kidney transplant rejection and salicylate poisoning. In addition, the signals that lead a cell to necrosis or apoptosis remain to be elucidated. Alternatively, infiltrating microglia near a focus of radiation necrosis may be mistaken for a malignancy in a treated glioma. The venom consists of proteins, polypeptides, and enzymes that cause necrosis and hemolysis. Polymorphonuclear leukocyte infiltrates were present in the glomerular tufts, and many glomeruli displayed segmental necrosis. The venom has vasoconstrictive properties that can lead to cyanosis and necrosis, with poor wound healing and infection. I was once called to give an opinion over a case of femoral necrosis with suppuration following coxalgia in a young boy. Show More Sentences There was extensive but patchy acinar atrophy and parenchymal fibrosis, but no evidence of fat necrosis, pseudocyst formation, or calculi. A second-degree burn involves the epidermis, the dermis and usually forms blisters that may be the result of superficial or deep dermal necrosis. Further investigation of mechanisms of atypical liver necrosis after concentrated acetic acid ingestion is needed. At autopsy the adrenal glands often show hemorrhagic necrosis, an example of which is seen here. Defects of the hip's cartilage can be caused by osteoarthritis, rheumatoid arthritis, avascular necrosis, and trauma. She had undergone a right hip replacement because of avascular necrosis of the femoral head associated with use of corticosteroids. Biopsy from a peritoneal granuloma showed caseation necrosis and acid-fast bacilli. Histologically these lesions contain caseous necrosis and will eventually be absorbed or become calcified. In viral and autoimmune hepatitis, the collapse is recognized as bridging necrosis. Fibrin deposition was found in areas of fibrinoid necrosis within the glomeruli and in the interstitium. Neuronal inflammation and necrosis leads to severe pain or postherpetic neuralgia, which increases as the infection travels down the nerve. Unlike the hypersensitive necrotic reaction, this stem-tip necrosis can be a serious threat to soybean production. Epinephrine's vasoconstrictive properties can be a problem if extravasation into tissue occurs, and may result in skin necrosis. Eosinophils in vitro exhibited different stages of apoptosis, ending with secondary necrosis distinct from in vivo eosinophil cytolysis. A homograft with keratoplasty may be considered depending on the extent of the necrosis. In these respects, MRI is superior to ultrasonography or plain-film radiography in detecting tissue inflammation and necrosis. Multiple areas of tumor necrosis, cystic degeneration, and old hemorrhage were present. Cohesive or substitutive growth patterns and mitoses and necrosis should be absent. The nodes were tan-pink and had confluent areas of hemorrhage and necrosis. As with anterior packing, tissue necrosis can occur if a posterior pack is inserted improperly or balloons are overinflated. Show More Sentences Histology revealed a highly cellular, primarily diffuse and focally serpiginous growing tumor with pushing borders and extensive necrosis. To the best of our knowledge, skin necrosis of this nature by cetrimide has not been reported in a neonate. Livers were removed and the depth of necrosis was measured using Vernier calipers. The biopsy materials generally showed granulomatous or suppurative inflammation with ulceration and necrosis. There were also multiple areas of hemorrhagic necrosis with transmural extension. If the wound shows no signs of infection, necrosis, or residual contamination it can be closed by suture or a split skin graft. However, severe side effects may occur, including bilateral necrosis of the hip and gastric ulceration. Multifocal calcifications associated with tumor cell necrosis were also seen. Because cartilage derives its nutrition by diffusion from the perichondrium, necrosis and consequent structural deformity occurs. In severe exposure, necrosis of the respiratory epithelium leads to formation of a pseudomembrane, bronchial plugging, and bronchopneumonia. The differential diagnoses of the swelling, as visualized on MRI scan, were either a post-traumatic seroma or some form of fat necrosis. The sinusoidal pattern may have been due to sepsis or necrosis in adjacent tissues. The patient may present with corneal necrosis, dystrophy, ulceration, and abrasion. Both receive vaccines against vibriosis and the infections pasteurellosis, myxobacteriosis and viral nervous necrosis. The H-MESO1 xenografts used in these studies were grown s.c. in a mouse host, and some necrosis was evident as the tumors grew. These burns tend to be deep, as the corrosive agent continues to cause coagulative necrosis until completely removed. The plasma then finds the nearest grounded tissue and produces coagulative necrosis. A hyperemic rim marks the boundary between the area of coagulative necrosis and intact liver. Although no necrosis was present in the diagnostic lymph node, an adjacent lymph node showed total coagulative necrosis. Even minor amounts of myocardial necrosis would thus be classified as myocardial infarction. Show More Sentences Centrally within the larger foci of squamous metaplasia, necrosis may be seen. The combination increases the risk of soft tissue necrosis and osteonecrosis. Complications of this procedure include depigmentation of the skin, eyelid notching, madarosis, severe postoperative pain, edema, symblepharon, necrosis, and regrowth. Large abdominal periaortic and mesenteric lymph node masses, measuring up to 10 cm in diameter, grossly showed necrosis and sclerosis on sectioning. In internal necrosis the separation of dead bone from living proceeds in the manner already described, and the sequestrum is contained within the sequestral capsule. Skeinoid fibers and coagulative tumor necrosis were not seen. Under light microscopy, necrosis in both epidermis and dermis with extensive polymorphonuclear leucocyte infiltration in deep dermis were seen in all three groups. It may change colour sequentially from a red-purple to a dusky blue before progressing to necrosis and formation of bullae and eventually becoming haemorrhagic. Gymnasts' wrist injury includes distal radius stress fractures, scaphoid stress fracture, avascular necrosis of the capitate, ulnar carpal abutment, and dorsal impingement. The pathogenesis of necrosis in toxoplasma encephalitis is unclear. Pathologically, inflammation of the spinal cord meninges is coupled with varying degrees of underlying spinal necrosis, demyelination, and microglial influx. One patient, a 74-year-old woman with AD, had thrombosis of her superior sagittal sinus producing bilateral parasagittal regions of extensive hemorrhagic necrosis. When taken in larger doses, it becomes a potent hepatotoxin, generating fulminated hepatic and renal tubular necrosis which is lethal to humans and many species of animals. Supporting evidence for malignant transformation included high cellularity, increased mitotic activity, cellular pleomorphism, hemorrhage, and necrosis. Doing so can compromise blood flow to the nipple and lead to complications, such as necrosis of the skin along the incisions or nipple or aureole necrosis. The incidence of osteonecrosis or avascular necrosis has fallen as a result of new advances in immunosuppression and lower corticosteroid regimens. Thus, signs of soft tissue edema, erythema, ulceration, bullae, or necrosis should prompt the inclusion of necrotizing soft tissue infection in differential diagnoses. Patients with deep abscess, extensive bone or joint involvement, crepitus, substantial necrosis or gangrene, or necrotizing fasciitis may be candidates for surgery. He noted a strong association of this vascular phenomenon with tumor necrosis and showed it to be negative for calcium with von Kossa's and alizarin red methods. Central irregular hyperechogenic areas, blurred margins and central necrosis were most frequent in bacterial, tuberculous and cat scratch disease. Show More Sentences No areas of necrosis, mucinous change, or hemorrhage were identified. This finding suggests that most wounded cells reseal their membrane defect and that a relatively small fraction of wounded lung cells undergo necrosis. In the meantime, new diseases like furunculosis, infectious pancreatic necrosis, infectious salmon anaemia and cardiomyopathy syndrome are surfacing at regular intervals. There are large numbers of HRS cells with sarcomatous variants and a hypocellular background due to fibrosis and necrosis. Clinical alterations, such as ear or scrotal necrosis, were noted when observed. Camporesi EM, Vezzani G, Bosco G, Mangar D, Bernasek TL, Hyperbaric oxygen theraphy in femoral head necrosis. We also identified other surgical complications, including seroma, surgical wound infections, hematoma, and flap necrosis. Risk of avascular necrosis following short term megadose methylprednisolone treatment. Ambient ozone modifies the effect of tumor necrosis factor G-308A on bronchitic symptoms among children with asthma. Acrocyanosis, which was present on admission, had progressed to distal necrosis of the toes in both feet and part of the right hand. A synovial biopsy taken from the knee detected granulomatous inflammation with caseation necrosis. Autopsy showed enlargement of lungs, liver, and spleen with many abscessed areas of suppurative necrosis. Large cystic spaces, areas of hyalinization, and focal necrosis were identified. Other lesions included multiorgan congestion, necrosis of renal tubular epithelium, and moderate hemosiderosis in the liver and spleen. The venoms of some vermivorous species contain proteolytic enzymes which cause local necrosis at the site of injection in vertebrates. The histopathology examination showed a well-differentiated SCC with a wide range of tissue necrosis. Following laparoscopic ileocecectomy, pathology demonstrated haemorrhage, inflammation, oedema and full thickness necrosis of the caecal wall. Thus, relevant mid-term complications, such as humeral head necrosis, malunion and nonunion may not have been detected. The unmet need for antitumour necrosis factor therapy in ankylosing spondylitis. One has to deal with higher chances of infection on one hand, and higher complication rates, such as avascular necrosis, on the other hand. Show More Sentences Connor, of Renfrew, also suffers from avascular necrosis, meaning he can't run around the playground in case his fragile hip breaks. Soon afterwards he had a double hip replacement because of avascular necrosis, a condition where the blood supply to the bones dries up. Avascular necrosis occurs when blood vessels that supply the bone constrict, cutting off blood supply and causing bone death. Bullous formation with epidermal separation can extend to erythroderma, and necrosis is observed in later stages. Tumor necrosis factor-induced c-myc expression in the absence of mitogenesis is associated with inhibition of adipocyte differentiation. The Medical Examiner's autopsy showed microscopic evidence of focal myocyte necrosis on 2 of 34 slides. There was no evidence of small cell change, necrosis, or brain parenchymal invasion or chondromatous metaplasia. Frequent findings included bone marrow hypocellularity, reticulin fibrosis, necrosis, and plasmacytosis. Serum levels of tumor necrosis factor-alpha and interleukin-6 in ocular cicatricial pemphigoid. Politics is the art of the possible, not tricky-dick Nixon necrosis, Assad asininity, Gaddafi grave grovelling or Saddam spite. Histology results were consistent with areas of fibrosis and fat necrosis from prior methylene blue sentinel node injection. Clusters affected by bunchstem necrosis are identified by necrotic rachis tissue, with shriveled berries distal to the necrotic tissue. Adjacent brain tissue showed areas of coagulative necrosis, thrombosis, and fresh haemorrhage. Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside. Histopathologic analysis confirmed oocysts in the small intestine and showed intestinal pathologic lesions of hyperplasia and necrosis. Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. Secretion of tumour necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles. Interleukin-6 and tumour necrosis factor alpha are inflammatory cytokines and the main inducers of the secretion of CRP in the liver. Focal necrosis may be seen, and mitoses and apoptotic bodies are usually numerous. Macroscopically, pleomorphic sarcomas are nodular or multinodular, tan-white to gray tumors that may be associated with necrosis and hemorrhage. Show More Sentences Arteries and arterioles under the necrotic areas showed fibrinoid necrosis of the vascular walls. The epithelium is nearly always ulcerated, showing fibrinoid necrosis at the surface. A number of nonmalignant lesions can accumulate radionuclide, such as fibroadenoma, fibrocystic change, and fat necrosis. Intranasal drug abuse frequently leads to sinonasal complications, particularly sinus, nasal, and palatal necrosis. Flaps survived completely without necrosis or dehiscence, especially at the ventral site. In places, the tumor cells appeared anaplastic, with numerous pathologic mitoses and large areas of necrosis. Progression of striped jack nervous necrosis virus infection in naturally and experimentally infected striped jack Pseudocaranx dentex larvae. Focal necrosis of the adrenal gland was identified, together with glomerulitis and syncytial cell formation in the kidney. Multiple areas of necrosis may give leiomyosarcomas a cystic or multicystic appearance. Therefore, the major histologic findings were hepatic necrosis, nephrosis, and splenitis, with intranuclear inclusion bodies. Acute tubular necrosis was present, which was consistent with a nephrotoxin. These venoms produce not only extensive necrosis and hemorrhage that result in considerable tissue damage, but also coagulopathy and shock. Induction of hypoferremia and modulation of macrophage iron metabolism by tumor necrosis factor. Human tumor necrosis factor alpha gene regulation by virus and lipopolysaccharide. The organs of the body that had suffered colliquative necrosis and putrefaction suddenly came to life. In these cases, various combinations of suppurative and granulomatous necrosis were identified. Differential oligodendroglial expression of the tumor necrosis factor receptors in vivo and in vitro. The 533 nm KTP wavelength causes vaporization of prostate tissues with a 1 to 2 mm zone of coagulation necrosis. Ganciclovir chemoablation of herpes thymidine kinase suicide gene-modified tumors produces tumor necrosis and induces systemic immune responses. Gelsolin down-regulates lipopolysaccharide-inducedintraamniotic tumor necrosis factor-a production in the midtrimester of pregnancy. Show More Sentences Some appendages and paragnaths exhibited segmental cuticular degeneration and necrosis. Local haemorrhage and necrosis of the skin and underlying tissues, during anti-coagulant therapy with dicumarol or dicumacyl. Animal models have demonstrated necrosis of skeletal muscle, periosteum, perichondrial tissues, and evidence of meningitis and encephalitis. Abdominal CT indicated the presence of an edematous pancreas without any evidence of necrosis or ascites. One was due to tumor invasion and necrosis, which ruptured an emphysematous bleb. Necrotic pseudoxanthomatous nodules are composed of an area of central necrosis, surrounded by histiocytes and hyalinization. Higher magnification showing coagulative necrosis with loss of nuclear detail in hepatocytes. Histopathologically, fibrinopurulent bronchopneumonia with multifocal areas of necrosis and pleuritis was seen in the lungs of infected animals. There were scattered apoptotic cells, few binucleate cells, and multifocal areas of necrosis within the mass. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. Demyelination occurring during anti-tumor necrosis factor alpha therapy for inflammatory arthritides. Placental findings also include fibrinoid necrosis, atherosis of decidual vessels, and intimal thickening. Histopathology demonstrated irregular lamellar bone with hypocellular fibrous stroma, but no obvious atypia, mitotic activity or necrosis mimicking fibrous dysplasia. Intimal fibroplasia, lipohyalinosis, and fibrinoid necrosis were absent. Ultimately, he required bilateral video-assisted thoracoscopic surgery for decortication of the empyemas, at which time extensive left lower lobe necrosis was noted. Tumor necrosis factor-alpha production, inducible nitric oxide synthase, and endothelial nitric oxide synthase protein expression were analyzed in visceral adipose tissue. Anchorage-independent transformation has been observed in clone 41 cells treated with TPA, epidermal growth factor, tumor necrosis factor alpha, and other tumor promoters. Sometimes, biloma formation can be caused by bile duct necrosis. In recent years, it has also been explored for the treatment of the ischemic necrosis of the caput femoris, aphtha, bedsore and wound healing, and so on. Typical histologic lesions including small areas of necrosis and occasional capillary microthrombii within skeletal muscle and other organs are commonly reported. Show More Sentences The pathological post mortem diagnosis was acute pancreatitis, fat necrosis in pancreas with liver autolysis without any malignancy base Pathological report. Nature of the autofluorescent material in cerebrocortical necrosis. Purification and characterization of an inhibitor for tumor necrosis factor and lymphotoxin obtained from the serum ultrafiltrates of human cancer patients. Renal meronts and gametocytes were confined to the distal convoluted tubules and collecting ducts, and were associated with renal tubular necrosis and tubular obstruction. If not adequately and timely treated, such extravasations can lead to tissue necrosis that is sometimes of sufficient severity to require surgery including amputation. Caseation may occur in microscopic foci within the granulomas, or areas of necrosis may coalesce, forming a cold abscess, particularly when the immunity is high. The most severe and consistent microscopic lesion in mallards was myocardial degeneration and coagulative necrosis consistent with acute heart failure. Use of phentolamine to prevent necrosis due to levarterenol. Section of brain showing ischemia induced changes like loss of basophilia due to necrosis of the small neurons of the granular layer of brain in ischemic control group. Prospective assessment of body weight, body composition, and bone density changes in patients with spondyloarthropathy receiving anti-tumour necrosis factor-alpha treatment. Intraductal papilloma with 'comedo-like' necrosis, a diagnostic pitfall. Direct laryngoscopy revealed an extensive oedematous supraglottis with severe necrosis involving the laryngeal inlet, base of the tongue and right tonsillar bed. The Johns Hopkins group reported that muscle biopsies from 38 of 225 patients with myopathy showed myofiber necrosis without prominent inflammation. Moaddab and Eskandarlou report a case of chest wall necrosis and empyema resulting from attempting suicide by injection of petroleum into the pleural cavity. Widespread necrosis of mesenteric, omental, or other intra-abdominal fat is a relatively uncommon disorder, reported in several mammalian species, including humans. Tumor necrosis factor-related apoptosis-inducing ligand induces monocytic maturation of leukemic and normal myeloid precursors through a caspase-dependent pathway. Foci of necrosis, hyalinization and calcification were identified. The brain was edematous, and small foci of necrosis were found. A biopsy specimen taken 3 months later showed grade 3 hepatitis with bile ductular reaction, bridging hepatocytic necrosis and fibrosis, and regenerative nodule formation. Endoscopic tumor appearance is classified into ulcerated melanotic nodules, submucosal masses with ulcerations, and mass lesions with necrosis and melanosis. Show More Sentences Cellular pleomorphism, mitotic figures, and necrosis are absent. Kienbock disease is avascular necrosis of the scaphoid bone. Consequently, by using embolizing material to selectively embolize blood vessels in the hepatic artery, selective necrosis can be more effectively induced at the tumor site. Sectioning reveals variably cystic and fibrous areas filled by clear viscous fluid, while necrosis, hemorrhage, and purulence are only expected in secondarily infected cysts. Hematoxylin and eosin staining revealed no necrosis or mitotic figures. Pathology results showed necrosis and suppurative mixed inflammation. A transbronchial biopsy of the lesion indicated chronic inflammation, fibrotic proliferation of the interstitium, anthracosis, necrosis, and mucus collection. Mitoses are usually demonstrable, and necrosis may be present. Mitogen activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Examples from Classical Literature Eosinophilic swollen axonal and dendritic spheroids accompanied this neuronal necrosis. Purpura fulminans is a life-threatening hematologic emergency in which there is skin necrosis and disseminated intravascular coagulation. Microscopically, the lesions were characterized by epidermal hyperplasia and necrosis with ballooning degeneration, and intracytoplasmic inclusions in keratinocytes. It has been defined as a necrosis or death of the bone of the mandible or maxilla that may occur following radiation therapy for cancer in the oral and perioral region. We did not encounter the theoretical risk of skin bridge necrosis at the lateral aspects of the right subcostal and Rutherford-Morrison incisions where the two approximate. Find more words! 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Words that rhyme with necrosis What is the plural of necrosis? What is the adverb for necrosis? What is the adjective for necrosis? What is the noun for necrosis? Translations for necrosis Use our Sentence Generator Nearby Words necroses necropsy necropsies necropolis necrophobia necrophiliac necrotic necrotize necrotizing nectar nectarean nectareous 8-letter Words Starting With n ne nec necr necro necros necrosi