| In contrast, fasting, which reduces serum leptin, attenuates ozone-induced inflammation. |
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| Other important endocrine effects of leptin include immune function regulation, hematopoiesis, angiogenesis, and bone development. |
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| The absorbance measured is directly proportional to the concentration of human leptin present. |
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| Our bodies are thought to have a built-in system to measure levels of a key protein, leptin, which is produced in fatty tissue. |
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| Then the scientists mated mice deficient in the GIP receptor with mice that lack leptin, a hormone that signals satiety. |
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| They had unusual levels of leptin and ghrelin, both hormones involved in appetite. |
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| Apart from its role in regulation of fat metabolism, leptin may also regulate insulin release as part of an adipoinsular feedback. |
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| Injections of leptin have been used to help morbidly obese people with a deficiency of the hormone to lose weight. |
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| Among the topics for discussion are the roles of ghrelin and leptin in obesity. |
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| First, sleep deprivation lowers levels of the hormone leptin, an absence of which can trigger the overconsumption of carbohydrates. |
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| These include incretins that are licensed for use in diabetes and others that affect the leptin hormone, which creates a feeling of fullness. |
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| Sleep deprivation lowers leptin, a blood protein that suppresses appetite and seems to affect how the brain senses when the body has had enough food. |
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| Obese people are also believed to have a faulty receptor in their brains, which is meant to measure levels of leptin, a protein produced by fatty tissue. |
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| Fat cells produce leptin, a protein known to help trigger puberty. |
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| The thinner you become, the lower your leptin levels droop, and the more food it takes to satisfy your appetite. |
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| One of the primary benefits of cheat days is their effect on leptin levels in the body. |
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| However, when leptin levels drop, hunger signals go through the roof, often resulting in overeating. |
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| For example, in the cases of the heart-muscle cells and pancreatic cells mentioned above, dosing them with leptin keeps them healthy. |
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| He and his colleagues looked at leptin, another hormone that is known to regulate appetite and metabolism. |
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| Individuals with a high proportion of fat normally form more leptin than those with small fat depots. |
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| It increases the amount of ghrelin, a stomach hormone that drives appetite, and also decreases the amount of leptin, which makes your body believe it is starving. |
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| Neck, waist, and hip girth, skinfold thickness, and fasting serum levels of lipids, glucose, insulin, and leptin were compared between these two groups. |
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| It takes several weeks to restore the sensitivity of the body's leptin receptors. |
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| The hormone leptin tells the brain when we have consumed sufficient calories and can therefore stop eating. |
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| In addition, L-carnitine supplementation is also associated with a rise in the circulating level of leptin following feeding. |
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| Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin. |
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| In a rat study, sodium fluoride produced concentration-dependent inhibition of leptin secretion. |
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| Some scientists believe that the reason for the Pima's obesity is that their weight setpoints are higher than normal, and that their bodies have learned to ignore the chemical leptin, which usually promotes weight loss. |
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| An isolated single or double-stranded DNA molecule consisting of a nucleotide sequence which encodes a porcine adipocyte polypeptide leptin having the amino acid sequence of SEQ ID NO:4, or the complement to the DNA molecule. |
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| Only the other half, the parasympathetic system, remained unaffected. This suggests that previous attempts to use leptin as a weight-loss agent have been misconceived. |
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| In what is, admittedly, the least-tested part of their thesis, Dr Unger and Dr Scherer argue that other cells react to this increase in leptin concentration by becoming resistant to the hormone's effects. |
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| In cases of pathological overweight it is presumed that either too little leptin is produced or that the target cells in the hypothalamus are insensitive to leptin activity. |
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| These include mutations in the leptin gene, the melanocortin-4 receptor, cholesterol side-chain cleavage enzyme and PPAR gamma, a transcription factor. |
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| Studies have demonstrated the efficacy of Irvingia gabonensis in influencing four of the mechanisms responsible for weight gain, including loss of leptin sensitivity. |
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| The known effect of Irvingia gabonensis on leptin sensitivity, combined with proven efficacy of nutrients and phytonutrients on mechanisms responsible for weight gain. |
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| Use of a strain of Lactobacillus plantarum for the preparation of a medicament for reducing the risk factors involved in the metabolic syndrome, including increased blood pressure, high insulin level, and high leptin level. |
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| Irvingia gabonensis is without doubt the most effective phytonutrient for helping to restore leptin sensitivity and neutralise the various mechanisms involved in gaining body fat. |
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| When overweight subjects are given Irvingia, their C-reactive protein levels fall and as a result, less C-reactive protein is available to block leptin activity. |
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| Use of the gene encoding the pancreatitis associated protein I, or a functional fragment thereof, to screen for molecules, which interfere directly or indirectly with the late leptin induction. |
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| Then antiserum against bovine leptin was obtained by its immunization in rabbits. |
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| Other studies have found evidence of leptin receptors, proteins that help a cell detect the hormone, on astrocytes. |
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| Most studies on the physiological role of leptin in teleosts address its function in appetite, body weight regulation, and metabolism. |
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| As for the thin and thinning, leptin remains an important consideration. |
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| A truncated form of leptin receptor, Ob-Ra, was predominant in placenta and vascular tissues. |
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| This condition favours the production of adiponectin in relation to leptin which also allows adiponectin to block the prohypertrophic effect of leptin. |
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| This protein is a receptor for leptin and is involved in the regulation of fat metabolism and of a novel hematopoietic pathway required for normal lymphopoiesis. |
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| Individuals who are deficient in leptin fail to initiate puberty. |
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| Histamine potentiates leptin and its anorexigenic influence. |
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| Immunohistochemical and ultrastructural localization of leptin and leptin receptor in human white adipose tissue and differentiating human adipose cells in primary culture. |
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| The model is based on overall energy balance of the body, which is regulated by neurocentric sensing of fat-mass accumulation via insulin and leptin. |
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| The position of gut hormones and adipokines has been delineated with particular advertence to ghrelin, PYY and leptin and their prospective pharmacotherapeutic denouement. |
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| Leptin is a hormone produced by adipocytes that acts in the hypothalamus to signal satiety and to increase basal metabolic rate. |
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| Leptin increases activity in sympathetic nerves in the kidney, brown adipose tissue, hind limbs, and adrenal medulla. |
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| The gene altered in the giant rats makes the protein Leptin, a hormone released by fat cells as an appetite regulator. |
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| Leptin is a hormone secreted by fat cells that is key to maintaining energy balance in the body. |
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| Leptin levels rise throughout childhood and play a part in allowing the arcuate nucleus to resume operation. |
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| Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. |
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| Leptin in the regulation of immunity, inflammation, and haematopoiesis. |
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