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Contexts (chiefly of a drug) Comparative for reducing functional or nervous activity Comparative for feeling or bringing no joy Adjective ▲ (chiefly of a drug) Comparative for reducing functional or nervous activity dreamier tranquiler peacefuller milder placider calmer quieter gentler comfortabler lazier balmier benigner lighter mellower tenderer more sedative more narcotic more soothing more relaxing more anodyne more calmative more comforting more lenitive more ataractic more ataraxic more palliative more restful more reassuring more analgesic more soporific more reposeful more demulcent more romantic more therapeutic more relieving more emollient more alleviative more alleviatory more mitigatory more mitigative more paregoric more carefree more leisurely more anaestheticUK more anestheticUS more indulgent more serene more undisturbed more untroubled more halcyon more chilled more temperate more relaxed more consolatory “Alcohol has a stronger and faster depressant effect on the brain, causing memory loss and problems with coordination.” Adjective ▲ Comparative for feeling or bringing no joy sadder miserabler unhappier glummer gloomier forlorner mournfuller dolefuler lower woefuller wretcheder sorrier moroser droopier badder sombrerUK sombererUS sullener drearier dourer mopier blacker heavier more joyless more depressed more dejected more despondent more downcast more disconsolate more melancholy more sorrowful more crestfallen more blue more woebegone more heartbroken more melancholic more inconsolable more dispirited more heartsick more brokenhearted more dismal more heartsore more cheerless more lugubrious more depressing more mirthless more humorlessUS more humourlessUK more saturnine more saddening more low-spirited more heavy-hearted more down in the mouth more down in the dumps Find more words! 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